Ritalin and Cogentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Cogentin (benztropine mesylate). Common drug interactions include vomiting among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Cogentin. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

On Jul, 27, 2026

43 people who take Ritalin and Cogentin together, and have interactions are studied.

What are the common drug interactions of Ritalin and Cogentin, by gender? *:

female:

Vomiting
Weight decreased
Back pain
Cough
Dry mouth
Fatigue (feeling of tiredness)
Hypersensitivity
Leukopenia (less number of white blood cells in blood)
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)

male:

Weight increased
Homicidal ideation (thoughts about human killing another human)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Mania (a state of abnormally elevated or irritable mood)
Muscle twitching
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Suicide attempt
Sweating increased (excess sweating)
Vision blurred

What are the common drug interactions of Ritalin and Cogentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Muscle twitching
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)

10-19:

Constipation
Headache (pain in head)
Sweating increased (excess sweating)
Weight increased
Abdominal pain upper
Abnormal behaviour
Acute lymphocytic leukaemia (cancer of the white blood cells)
Aggression
B-cell type acute leukaemia (cancer of the white blood cells)
Chest pain

20-29:

Back pain
Bone pain
Granulocytopenia (lack of granulocyte)
Neutropenia (an abnormally low number of neutrophils)
Pain in extremity

30-39:

Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Migraine (headache)
Mobility decreased (ability to move is reduced)
Muscle spasms (muscle contraction)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Negativism (negative thoughts)
Nervousness
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Nightmare (unpleasant dream)

40-49:

Dyspnoea (difficult or laboured respiration)
Chest pain
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Delusional perception (delusional perception describes, confusingly, a true perception, to which a patient attributes a false meaning)
Dizziness
Headache (pain in head)
Influenza like illness
Insomnia (sleeplessness)
Memory impairment

50-59:

Death
Decreased appetite
Dizziness
Dysarthria (speech disorder)
Fall
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Orthostatic hypertension (a medical condition consisting of a sudden increase in blood pressure when a person stands up)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)

60+:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)
Migraine (headache)
Oedema peripheral (superficial swelling)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Pancreatitis (inflammation of pancreas)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 18.60%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 11.63%
Bipolar Disorder (mood disorder): 5 people, 11.63%
Stress And Anxiety: 4 people, 9.30%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 9.30%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 9.30%
Insomnia (sleeplessness): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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