Ritalin and Combivent drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Combivent (albuterol sulfate; ipratropium bromide). Common drug interactions include pain among females and fatigue among males.
The phase IV clinical study analyzes what interactions people have when they take Ritalin and Combivent. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.
What is Ritalin?
Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.
What is Combivent?
Combivent has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in asthma. eHealthMe is studying from 35,341 Combivent users. Check the latest studies of Combivent.
80 people who take Ritalin and Combivent together, and have interactions are studied.

What are the common drug interactions of Ritalin and Combivent, by gender? *:
female:
- Pain
- Therapeutic response unexpected
- Anxiety
- Arthralgia (joint pain)
- Constipation
- Decreased appetite
- Fibromyalgia (a long-term condition which causes pain all over the body)
- Insomnia (sleeplessness)
- Lung disorder (lung disease)
- Mania (a state of abnormally elevated or irritable mood)
male:
- Fatigue (feeling of tiredness)
- Pain
- Constipation
- Dyspnoea (difficult or laboured respiration)
- Flatulence (flatus expelled through the anus)
- Gait disturbance
- Hypertension (high blood pressure)
- Pain in extremity
- Staphylococcal infection (an infection with staphylococcus bacteria)
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
What are the common drug interactions of Ritalin and Combivent, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Loss of consciousness
- Abdominal pain upper
- Abnormal behaviour
- Aggression
- Chest pain
- Intentional self-injury
- Irritability
- Mood swings (an extreme or rapid change in mood)
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Suicidal ideation
20-29:
n/a
30-39:
- Bipolar disorder (mood disorder)
- Decreased appetite
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Hallucination, auditory (perceiving sounds without auditory stimulus)
- Hypertensive heart disease
- Insomnia (sleeplessness)
- Multiple drug overdose intentional
- Nasopharyngitis (inflammation of the nasopharynx)
- Nausea (feeling of having an urge to vomit)
- Obesity (having too much body fat)
40-49:
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
- Abscess (pus)
- Acne (skin problems that cause pimples)
- Anaphylactic reaction (serious allergic reaction)
- Arthralgia (joint pain)
- Blood carbon dioxide decreased
- Blood cholesterol increased
- Blood triglycerides increased
- Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
50-59:
- Arthralgia (joint pain)
- Asthenia (weakness)
- Back pain
- Blood creatinine increased
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Cervical spinal stenosis (narrowing of the spinal canal in the neck)
- Choking (mechanical obstruction of the flow of air from the environment into the lungs)
- Conjunctivitis (pink eye)
- Constipation
- Dysarthria (speech disorder)
60+:
- Dyspnoea (difficult or laboured respiration)
- Fatigue (feeling of tiredness)
- Bradycardia (abnormally slow heart action)
- Cardiac failure congestive
- Chest pain
- Dehydration (dryness resulting from the removal of water)
- Flatulence (flatus expelled through the anus)
- Gait disturbance
- Haematoma (collection of blood outside the blood vessels)
- Hypertension (high blood pressure)
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 28 people, 35.00%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 22.50%
- Pain: 7 people, 8.75%
- Drowsiness: 7 people, 8.75%
- Stress And Anxiety: 6 people, 7.50%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 7.50%
- High Blood Cholesterol: 5 people, 6.25%
- Dyspnea (difficult or laboured breathing): 5 people, 6.25%
- Depression: 5 people, 6.25%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.00%
* Approximation only. Some reports may have incomplete information.
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Ritalin and Combivent:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Ritalin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Combivent:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Ritalin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Combivent and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
- Yektas ?, Samurcu ND, Tufan AE, "Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report", Journal of Clinical Psychopharmacology, 2017 Aug .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
- Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
- Coskun, M., & Adak, I. , "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2014 Jan .
- Yalcin O, Aslan AA, Sari BA, Turkbay T, "Possible methylphenidate related hoarseness and disturbances of voice quality: two pediatric cases", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2012 Sep .
- Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
- Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
- Yektas ?, Samurcu ND, Tufan AE, "Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report", Journal of Clinical Psychopharmacology, 2017 Aug .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
- Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
- Coskun, M., & Adak, I. , "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2014 Jan .
- Yalcin O, Aslan AA, Sari BA, Turkbay T, "Possible methylphenidate related hoarseness and disturbances of voice quality: two pediatric cases", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2012 Sep .
- Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on methylphenidate hydrochloride and albuterol sulfate; ipratropium bromide (the active ingredients of Ritalin and Combivent, respectively), and Ritalin and Combivent (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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