Rocephin and Marcaine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Marcaine (bupivacaine hydrochloride). Common drug interactions include swelling among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Marcaine. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Marcaine?

Marcaine has active ingredients of bupivacaine hydrochloride. It is often used in pain. eHealthMe is studying from 4,026 Marcaine users. Check the latest studies of Marcaine.

On Jul, 13, 2026

30 people who take Rocephin and Marcaine together, and have interactions are studied.

Rocephin and Marcaine drug interactions.

What are the common drug interactions of Rocephin and Marcaine, by gender? *:

female:

Swelling
Synovial cyst (cyst of joint filled with synovial fluid)
Synovitis (inflammation of the synovial membrane)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Tooth disorder (tooth disease)
Tooth loss
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Unresponsive to stimuli
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Vein disorder

male:

Hypotension (abnormally low blood pressure)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

What are the common drug interactions of Rocephin and Marcaine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Anaemia (lack of blood)
Hip arthroplasty
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)

40-49:

Abscess limb (limb infection)
Anal abscess
Asthenia (weakness)
Burning sensation
Cerebrospinal fluid leakage
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Eye disorder
Flat affect (absence of emotional response to a situation)
Headache (pain in head)
Hypotension (abnormally low blood pressure)

50-59:

Pulse pressure decreased
Rash erythematous (redness of the skin)
Respiratory tract infection
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cerebral oedema (swelling of brain)
Coma (state of unconsciousness lasting more than six hours)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Upper respiratory tract infection
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)

60+:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Rib fracture
Cellulitis (infection under the skin)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
Colonic polyp (extra part of colon tissue grow in intestine)
Conjunctivitis (pink eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Delirium (wild excitement)
Dental caries

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.67%
Headache (pain in head): 4 people, 13.33%
High Blood Pressure: 4 people, 13.33%
Type 2 Diabetes: 3 people, 10.00%
Hypersensitivity: 3 people, 10.00%
Urinary Tract Infection: 3 people, 10.00%
Wound: 2 people, 6.67%
Insomnia (sleeplessness): 2 people, 6.67%
Back Pain: 2 people, 6.67%
Cellulitis (infection under the skin): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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