Rose hip and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rose hip (rose hip) and Methotrexate (methotrexate sodium). Common drug interactions include arthropathy among females and injection site haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Rose hip and Methotrexate. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Rose hip?

Rose hip has active ingredients of rose hip. eHealthMe is studying from 330 Rose hip users. Check the latest studies of Rose hip.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.



On Jul, 29, 2026

17 people who take Rose hip and Methotrexate together, and have interactions are studied.

Rose hip and Methotrexate drug interactions.

What are the common drug interactions of Rose Hip and Methotrexate, by gender? *:

female:

  1. Arthropathy
  2. Pain
  3. Drug ineffective
  4. Fatigue (feeling of tiredness)
  5. Injury
  6. Joint swelling
  7. Mobility decreased (ability to move is reduced)
  8. Abdominal discomfort
  9. Alopecia (absence of hair from areas of the body)
  10. Glossodynia (a burning or painful sensation in the tongue)

male:

  1. Injection site haemorrhage (bleeding from injection site)
  2. Injection site pain
  3. Somnambulism (sleep walking)
  4. Somnolence (a state of near-sleep, a strong desire for sleep)
  5. Tendon disorder (disease of tendon)
  6. Fall
  7. Injection site haematoma (localized swelling filled with blood at injection site)
  8. Injection site swelling
  9. Lumbar vertebral fracture
  10. Staphylococcal infection (an infection with staphylococcus bacteria)

What are the common drug interactions of Rose Hip and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Swelling
  2. Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
  3. Wound
  4. Injection site haemorrhage (bleeding from injection site)
  5. Injection site pain
  6. Fall
  7. Injection site haematoma (localized swelling filled with blood at injection site)
  8. Injection site swelling
  9. Lumbar vertebral fracture
  10. Pain

50-59:

  1. Arthropathy
  2. Drug ineffective
  3. Injury
  4. Joint swelling
  5. Mobility decreased (ability to move is reduced)
  6. Death
  7. Abdominal discomfort
  8. Alopecia (absence of hair from areas of the body)
  9. Anti-cyclic citrullinated peptide antibody positive
  10. Arthralgia (joint pain)

60+:

  1. Pain
  2. Accident
  3. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Arthropathy
  6. Asthenia (weakness)
  7. Diarrhoea
  8. Fatigue (feeling of tiredness)
  9. Feeling jittery
  10. Injection site pain

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 5 people, 29.41%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 29.41%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 23.53%
  4. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 23.53%
  5. Gout (uric acid crystals building up in the body): 3 people, 17.65%
  6. Pain: 3 people, 17.65%
  7. Depression: 3 people, 17.65%
  8. High Blood Pressure: 2 people, 11.76%
  9. Joint Pain: 2 people, 11.76%
  10. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rose hip and Methotrexate:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rose hip:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rose hip and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methotrexate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on rose hip and methotrexate sodium (the active ingredients of Rose hip and Methotrexate, respectively), and Rose hip and Methotrexate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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