Roxicodone and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicodone (oxycodone hydrochloride) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include anxiety among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicodone and Sudafed. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicodone?

Roxicodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 20,099 Roxicodone users. Check the latest studies of Roxicodone.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

On Jul, 20, 2026

22 people who take Roxicodone and Sudafed together, and have interactions are studied.

Roxicodone and Sudafed drug interactions.

What are the common drug interactions of Roxicodone and Sudafed, by gender? *:

female:

Anxiety
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
Neck pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Partner stress

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Headache (pain in head)
Duodenal ulcer
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Ileus (a painful obstruction of the ileum or other part of the intestine)

What are the common drug interactions of Roxicodone and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Headache (pain in head)
Rash
Swelling face
Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Neck pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Partner stress

40-49:

Burning sensation
Sinusitis (inflammation of sinus)
Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Central nervous system neoplasm (tumour of central nervous system)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Limb discomfort (discomfort in leg)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)

50-59:

Burning sensation
Cerebral disorder (brain disease)
Cerebral haemorrhage (bleeding within the brain)
Craniocerebral injury (injury to cranium and brain)
Crying
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Insomnia (sleeplessness)

60+:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Fall
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Staphylococcal bacteraemia (a bacterial infection of blood)

What are the existing conditions these people have? *

Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 6 people, 27.27%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 18.18%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 18.18%
Stress And Anxiety: 3 people, 13.64%
Sacroiliitis (an inflammation of the sacroiliac joint): 3 people, 13.64%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 13.64%
Nausea (feeling of having an urge to vomit): 3 people, 13.64%
Iron Deficiency Anaemia: 3 people, 13.64%
Hypersensitivity: 3 people, 13.64%
Birth Control: 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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