Rozerem and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rozerem (ramelteon) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include electrocardiogram st segment elevation among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Rozerem and Yaz. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Rozerem?

Rozerem has active ingredients of ramelteon. It is often used in insomnia. eHealthMe is studying from 7,539 Rozerem users. Check the latest studies of Rozerem.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

On Jul, 21, 2026

48 people who take Rozerem and Yaz together, and have interactions are studied.

What are the common drug interactions of Rozerem and Yaz, by gender? *:

female:

Electrocardiogram st segment elevation
Gallbladder disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrointestinal injury (injury to gastrointestinal tract)
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
Intestinal obstruction
Intracardiac thrombus (presence of a circumscribed mass with heart wall)
Respiratory distress (difficulty in breathing)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Troponin increased

male:

Balance disorder
Cerebellar haemorrhage (bleeding in cerebeller)
Intraocular pressure increased
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)
Acute sinusitis
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
Cardiac murmur (an heart sound in valve abnormality)
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)

What are the common drug interactions of Rozerem and Yaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Binge eating (pattern of disordered eating which consists of episodes of uncontrollable eating)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Injury
Murphy's sign positive
Nausea (feeling of having an urge to vomit)
Weight increased

20-29:

Pulmonary embolism (blockage of the main artery of the lung)
Anxiety
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Stress
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Abdominal pain
Abdominal pain upper
Biliary colic
Cholecystitis (infection of gallbladder)

30-39:

Injury
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory distress (difficulty in breathing)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Troponin increased
Brain natriuretic peptide increased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dyspnoea exertional (breathlessness or shortness of breath)
Hepatic congestion (liver congestion)

40-49:

Pulmonary embolism (blockage of the main artery of the lung)
Hypokalaemia (low potassium)
Respiratory alkalosis (elevated blood ph due to excess breathing)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Dizziness
Dyspnoea (difficult or laboured respiration)
Loss of consciousness
Menstruation irregular
Palpitations (feelings or sensations that your heart is pounding or racing)
Metrorrhagia (uterine bleeding at irregular intervals)

50-59:

Abdominal distension
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Headache (pain in head)
Hemicephalalgia (headache affecting one side of the head)
Listless (lack of interest, energy, or spirit)
Muscular weakness (muscle weakness)

60+:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Embolism arterial (blood clot that has travelled through your arteries and become stuck)
Haemorrhagic cerebral infarction (brain stroke with bleeding)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Intraocular pressure increased
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Premenstrual Syndrome: 12 people, 25.00%
Pain: 8 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 16.67%
Sleep Disorder: 7 people, 14.58%
Asthma: 6 people, 12.50%
Hypersensitivity: 6 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 10.42%
Depression: 5 people, 10.42%
Dysmenorrhea (painful menstruation): 5 people, 10.42%
Weight Decreased: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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