Sabril and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sabril (vigabatrin) and Ibuprofen (ibuprofen). Common drug interactions include ischaemia among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Sabril and Ibuprofen. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Sabril?

Sabril has active ingredients of vigabatrin. eHealthMe is studying from 12,445 Sabril users. Check the latest studies of Sabril.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

On Jul, 14, 2026

70 people who take Sabril and Ibuprofen together, and have interactions are studied.

What are the common drug interactions of Sabril and Ibuprofen, by gender? *:

female:

Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Lactic acidosis (low ph in body tissues)
Multi-organ failure (multisystem organ failure)
Mydriasis (a dilation of the pupil)
Pulseless electrical activity
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin discolouration (change of skin colour)
Somnolence (a state of near-sleep, a strong desire for sleep)
Unresponsive to stimuli

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Petit mal epilepsy (absence seizure)
Death
Pneumonia
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Balance disorder
Dysarthria (speech disorder)
Insomnia (sleeplessness)
Respiratory failure (inadequate gas exchange by the respiratory system)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Sabril and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

Dehydration (dryness resulting from the removal of water)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Acute respiratory distress syndrome
Anoxia (low oxygen)
Bradycardia (abnormally slow heart action)
Brain injury
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebral disorder (brain disease)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

2-9:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Acute respiratory failure
Influenza
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory distress (difficulty in breathing)
Rhinovirus infection
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Cough

10-19:

Pneumonia
Retinal dystrophy (progressive weakness and wasting of the retina)
Vomiting

20-29:

Apnoea (suspension of external breathing)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Seizure cluster (small group of seizure)
Urinary tract infection

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Postictal state
Fall
Fibula fracture
Tibia fracture (fracture of lower leg bone)
Blood albumin decreased
Blood pressure diastolic decreased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Diarrhoea
Lymphocyte percentage increased

40-49:

Amblyopia (lazy eye)
Gait disturbance
Vision blurred
Weight increased
Drug withdrawal convulsions
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Eye movement disorder
Visual impairment
Hidradenitis (chronic disease of a type of sweat gland)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

50-59:

Therapeutic response unexpected
Drug withdrawal convulsions
Chest pain
Limb injury
Contusion (a type of hematoma of tissue in which capillaries)
Facial pain
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Fall
Head injury
Incontinence (lack of moderation or self-control)

60+:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Petit mal epilepsy (absence seizure)
Pyrexia (fever)
Hot flush (sudden feelings of heat)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 28 people, 40.00%
Infantile Spasms: 22 people, 31.43%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 18 people, 25.71%
Partial Seizures (seizures which affect only a part of the brain at onset): 12 people, 17.14%
Fever: 9 people, 12.86%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 10.00%
Complex Partial Seizures (epileptic seizure): 7 people, 10.00%
Constipation: 6 people, 8.57%
Dyspnea (difficult or laboured breathing): 5 people, 7.14%
Nausea And Vomiting: 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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