Saizen and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Saizen (somatropin recombinant) and Methotrexate (methotrexate sodium). Common drug interactions include erythema among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Saizen and Methotrexate. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Saizen?

Saizen has active ingredients of somatropin recombinant. eHealthMe is studying from 3,122 Saizen users. Check the latest studies of Saizen.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 13, 2026

14 people who take Saizen and Methotrexate together, and have interactions are studied.

Saizen and Methotrexate drug interactions.

What are the common drug interactions of Saizen and Methotrexate, by gender? *:

female:

Erythema (redness of the skin)
Herpes zoster
Infection
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Psoriasis (immune-mediated disease that affects the skin)
Skin infection
Mastitis (inflammation of breast)
Ear infection
Infusion site swelling
Pituitary tumour

male:

Hypertension (high blood pressure)
Pain in extremity
Local swelling (swelling at the site of some application of substance or injury)
Vomiting
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Seasonal allergy (allergic condition due to certain season)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Arthralgia (joint pain)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Saizen and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood insulin increased
Hypertension (high blood pressure)
Joint dislocation (a joint position is changed from normal position)
Nocturia (the need to get up in the night to urinate)
Pain in extremity
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Seasonal allergy (allergic condition due to certain season)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Weight decreased
Arthralgia (joint pain)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Ear infection
Erythema (redness of the skin)
Injection site erythema (redness at injection site)
Injection site swelling
Sinusitis (inflammation of sinus)
Localised infection (infection at the single location)
Cellulitis (infection under the skin)
Influenza
Adverse drug reaction
Herpes zoster

60+:

n/a

What are the existing conditions these people have? *

Growth Hormone Deficiency: 11 people, 78.57%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 8 people, 57.14%
Immune System Disorder: 6 people, 42.86%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 14.29%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 7.14%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 1 person, 7.14%
Growth Retardation (delayed growth): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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