Salagen and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Salagen (pilocarpine hydrochloride) and Profen (ibuprofen). Common drug interactions include asthenia among females and blood testosterone decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Salagen and Profen. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Salagen?

Salagen has active ingredients of pilocarpine hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,966 Salagen users. Check the latest studies of Salagen.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 15, 2026

69 people who take Salagen and Profen together, and have interactions are studied.

What are the common drug interactions of Salagen and Profen, by gender? *:

female:

Asthenia (weakness)
Erythema (redness of the skin)
Eye irritation
Neuropathy peripheral (surface nerve damage)
Oropharyngeal pain
Pruritus (severe itching of the skin)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Urinary tract infection
Blood pressure increased
Dyspnoea (difficult or laboured respiration)

male:

Blood testosterone decreased
Muscle hypertrophy (a term for the growth and increase of the size of muscle cells)
Nasopharyngitis (inflammation of the nasopharynx)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Weight increased

What are the common drug interactions of Salagen and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Death
Heart rate irregular
Vomiting
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anaemia of malignant disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

50-59:

Osteonecrosis (death of bone)
Periodontitis (inflammation of the tissue around the teeth)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Renal disorder (kidney disease)
Scleroderma (hard skin)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Anxiety
Blood pressure increased
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)

60+:

Anaemia (lack of blood)
Asthenia (weakness)
Adenomatous polyposis coli ((fap) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine)
Antiphospholipid antibodies positive
Anxiety
Aortic valve sclerosis (narrowing of the aortic valve)
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Blood cholesterol increased
Blood immunoglobulin g increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 23.19%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 11.59%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.14%
Immunodeficiency Common Variable: 7 people, 10.14%
Drowsiness: 7 people, 10.14%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.25%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 5.80%
Dry Mouth: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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