Sanctura and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sanctura (trospium chloride) and Zoloft (sertraline hydrochloride). Common drug interactions include anger among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Sanctura and Zoloft. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Sanctura?

Sanctura has active ingredients of trospium chloride. It is often used in urinary incontinence. eHealthMe is studying from 1,649 Sanctura users. Check the latest studies of Sanctura.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 06, 2026

87 people who take Sanctura and Zoloft together, and have interactions are studied.

What are the common drug interactions of Sanctura and Zoloft, by gender? *:

female:

Anger
Apathy
Chills (felling of cold)
Diplopia (double vision)
Dyspepsia (indigestion)
Dysstasia (difficulty in standing)
Dysuria (painful or difficult urination)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Flatulence (flatus expelled through the anus)
Fracture

male:

Fall
Gait disturbance
Balance disorder
Blindness
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Compression fracture (fracture due to pressure caused by injury)
Dental caries
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Sanctura and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Viral infection

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Benign colonic neoplasm (benign (non-cancerous) tumours of the adrenal gland)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diaphragmatic hernia (defect or hole in the diaphragm that allows the abdominal contents to move into the chest cavity)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Gastritis (inflammation of stomach)
Headache (pain in head)

50-59:

Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Middle ear effusion (fluid in middle ear)
Migraine (headache)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasal septum deviation (deviated nasal septum)
Oedema peripheral (superficial swelling)
Type 2 diabetes mellitus
Weight increased
Abdominal pain upper
Acute respiratory failure

60+:

Gait disturbance
Balance disorder
Constipation
Nausea (feeling of having an urge to vomit)
Activities of daily living impaired
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthropathy
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 23 people, 26.44%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 12 people, 13.79%
Constipation: 12 people, 13.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 12.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.34%
High Blood Pressure: 7 people, 8.05%
Asthma: 6 people, 6.90%
Thyroid Diseases: 5 people, 5.75%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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