Septocaine and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Septocaine (articaine hydrochloride; epinephrine bitartrate) and Zoloft (sertraline hydrochloride). Common drug interactions include abscess oral among females.

The phase IV clinical study analyzes what interactions people have when they take Septocaine and Zoloft. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Septocaine?

Septocaine has active ingredients of articaine hydrochloride; epinephrine bitartrate. eHealthMe is studying from 1,182 Septocaine users. Check the latest studies of Septocaine.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 18, 2026

25 people who take Septocaine and Zoloft together, and have interactions are studied.

Septocaine and Zoloft drug interactions.

What are the common drug interactions of Septocaine and Zoloft, by gender? *:

female:

Abscess oral (abscess in the mouth)
Anaemia (lack of blood)
Fall
Fatigue (feeling of tiredness)
Gastrinoma (a tumour in the pancreas or duodenum that secretes excess of gastrin leading to ulceration)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Myeloproliferative disorder (a group of diseases in which the bone marrow makes too many red blood cells, white blood cells, or platelets)
Nephrolithiasis (calculi in the kidneys)

male:

n/a

What are the common drug interactions of Septocaine and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Presyncope
Respiratory disorder (respiratory disease)
Arrhythmia (irregular heartbeat)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Cardiotoxicity (damage to the heart muscle)
Disturbance in attention
Feeling hot
Hemiparesis (weakness on one side of the body)
Memory impairment
Muscle twitching

50-59:

Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Abscess oral (abscess in the mouth)
Adenoma benign (non-cancerous tumour -secreting)
Cardiomegaly (increased size of heart than normal)
Chest pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Choroidal detachment (separation of vascular layer of the eye)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Compression fracture (fracture due to pressure caused by injury)
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Pain: 17 people, 68.00%
High Blood Pressure: 17 people, 68.00%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 17 people, 68.00%
Local Anaesthesia: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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