Leukine and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leukine (sargramostim) and Synthroid (levothyroxine sodium). Common drug interactions include headache among females and oedema peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Leukine and Synthroid. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Leukine?

Leukine has active ingredients of sargramostim. eHealthMe is studying from 2,188 Leukine users. Check the latest studies of Leukine.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

On Jul, 18, 2026

57 people who take Leukine and Synthroid together, and have interactions are studied.

Leukine and Synthroid drug interactions.

What are the common drug interactions of Leukine and Synthroid, by gender? *:

female:

Headache (pain in head)
Hepatic steatosis (fatty liver disease)
Neutropenia (an abnormally low number of neutrophils)
Oedema (fluid collection in tissue)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Platelet count decreased
Vertigo
Weight decreased
Abdominal discomfort
Abdominal pain lower

male:

Oedema peripheral (superficial swelling)
Respiratory tract infection
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Sinusitis (inflammation of sinus)
Cough
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Drug ineffective

What are the common drug interactions of Leukine and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Pyrexia (fever)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vaginal haemorrhage (vaginal bleeding)
White blood cell count decreased

40-49:

Fatigue (feeling of tiredness)
Full blood count decreased
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)

50-59:

Arrhythmia (irregular heartbeat)
Blood pressure diastolic decreased
Chest pain
Erythema (redness of the skin)
Hypersensitivity
Hyperthyroidism (over activity of the thyroid gland)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Lethargy (tiredness)
Limb discomfort (discomfort in leg)

60+:

Diarrhoea
Dehydration (dryness resulting from the removal of water)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Osteonecrosis (death of bone)
Tooth extraction
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Cough

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 15 people, 26.32%
Prostate Cancer: 10 people, 17.54%
Pain: 5 people, 8.77%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 5 people, 8.77%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 7.02%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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