Seroquel and Intuniv drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Seroquel (quetiapine fumarate) and Intuniv (guanfacine hydrochloride). Common drug interactions include rash among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Seroquel and Intuniv. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.

What is Intuniv?

Intuniv has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 3,959 Intuniv users. Check the latest studies of Intuniv.

On Jul, 10, 2026

69 people who take Seroquel and Intuniv together, and have interactions are studied.

What are the common drug interactions of Seroquel and Intuniv, by gender? *:

female:

Rash
Skin fissures (a crack in the skin)
Surgery
Weight decreased
Weight fluctuation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Aggression
Irritability
Overdose

male:

Weight increased
Fatigue (feeling of tiredness)
Lower respiratory tract infection
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Oropharyngeal pain
Staphylococcal infection (an infection with staphylococcus bacteria)
Syncope (loss of consciousness with an inability to maintain postural tone)
Drug abuse
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Seroquel and Intuniv, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain
Abnormal behaviour
Aggression
Disturbance in attention
Drug administration error
Enuresis (repeated inability to control urination)
Excessive eye blinking (excessive blinking is dry eyes)
Headache (pain in head)
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)

10-19:

Pancreatitis (inflammation of pancreas)
Type 2 diabetes mellitus
Abnormal behaviour
Affect lability (emotional incontinence)
Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Apathy
Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Crying
Death

20-29:

Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Completed suicide (act of taking one's own life)
Abnormal behaviour
Anger
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug intolerance (drug sensitivity)
Glossodynia (a burning or painful sensation in the tongue)
Headache (pain in head)
Joint swelling

30-39:

Drug abuse
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Overdose
Dyspnoea (difficult or laboured respiration)
Hypersensitivity
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

40-49:

Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Escherichia infection (bacterial infection by escherichia coli)
Haematuria (presence of blood in urine)
Heart rate increased
Productive cough
Pyrexia (fever)
Renal aneurysm
Renal failure (kidney dysfunction)
Renal necrosis (kidney damaged)

50-59:

Suicidal ideation
Aggression
Death
Headache (pain in head)
Mood altered (changes in mood)
Nonspecific reaction (unspecified reaction)

60+:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the existing conditions these people have? *

Asthma: 10 people, 14.49%
Drowsiness: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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