Sertraline hydrochloride and Hctz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline hydrochloride (sertraline hydrochloride) and Hctz (hydrochlorothiazide). Common drug interactions include chronic kidney disease among females and drug level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline hydrochloride and Hctz. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline hydrochloride?

Sertraline hydrochloride has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 28,199 Sertraline hydrochloride users. Check the latest studies of Sertraline hydrochloride.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

On Jul, 10, 2026

31 people who take Sertraline hydrochloride and Hctz together, and have interactions are studied.

Sertraline hydrochloride and Hctz drug interactions.

What are the common drug interactions of Sertraline Hydrochloride and Hctz, by gender? *:

female:

Chronic kidney disease
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Decreased appetite
Activated partial thromboplastin time prolonged
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Contusion (a type of hematoma of tissue in which capillaries)
Death
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)

male:

Drug level increased
Overdose
Dementia (madness)
Diplopia (double vision)
Dizziness
Gait disturbance
Hypersomnia (excessive daytime sleepiness (eds))
Parkinson's disease
Reading disorder (problem in areas of the brain that help interpret language)
Speech disorder

What are the common drug interactions of Sertraline Hydrochloride and Hctz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug level increased
Overdose
Unresponsive to stimuli

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Adverse event
Irritability
Nephropathy (damage to or disease of a kidney)

50-59:

Chronic kidney disease
Drug intolerance (drug sensitivity)
Ear discomfort
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Pruritus (severe itching of the skin)

60+:

Death
Chronic kidney disease
Dementia (madness)
Diplopia (double vision)
Dizziness
Fatigue (feeling of tiredness)
Gait disturbance
Hypersomnia (excessive daytime sleepiness (eds))
Parkinson's disease
Reading disorder (problem in areas of the brain that help interpret language)

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 16.13%
High Blood Cholesterol: 4 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.90%
Asthma: 4 people, 12.90%
Pain: 3 people, 9.68%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 9.68%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.45%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.45%
Bladder Disorder: 2 people, 6.45%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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