Serzone and Dilaudid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Dilaudid (hydromorphone hydrochloride). Common drug interactions include gait disturbance among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Dilaudid. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

On Jul, 13, 2026

27 people who take Serzone and Dilaudid together, and have interactions are studied.

What are the common drug interactions of Serzone and Dilaudid, by gender? *:

female:

Gait disturbance
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Impaired driving ability
Palpitations (feelings or sensations that your heart is pounding or racing)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thermal burn (burn by heat)
Tremor (trembling or shaking movements in one or more parts of your body)
Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)

male:

Confusional state
Dehydration (dryness resulting from the removal of water)
Pancreatitis (inflammation of pancreas)
Abdominal discomfort
Blood triglycerides increased
Diabetic coma
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Hyperglycaemia (high blood sugar)

What are the common drug interactions of Serzone and Dilaudid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Communication disorder (speech and language disorder)
Confusion
Delusion (a false belief or opinion)
Drug effect increased
Hearing impaired
Irritability
Libido decreased (loss of interest in sex)
Sedation

10-19:

n/a

20-29:

Pyrexia (fever)
Abdominal pain
Abdominal pain upper
Blood glucose decreased
Cellulitis (infection under the skin)
Coma (state of unconsciousness lasting more than six hours)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

30-39:

Blood triglycerides increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hypertension (high blood pressure)
Metabolic syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease)
Obesity (having too much body fat)
Pancreatitis (inflammation of pancreas)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Abdominal pain

40-49:

Mitral valve incompetence (inefficient heart valve)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Panic disorder
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Presyncope
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Sleep disorder
Snoring
Social problem

50-59:

Confusional state
Dizziness
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Palpitations (feelings or sensations that your heart is pounding or racing)
Apnoea (suspension of external breathing)
Disturbance in attention
Drug effect decreased
Dysarthria (speech disorder)
Gait disturbance

60+:

Abdominal pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Thrombosis (formation of a blood clot inside a blood vessel)
Chronic kidney disease
Compression fracture (fracture due to pressure caused by injury)
Diarrhoea
Fall

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 18.52%
High Blood Pressure: 4 people, 14.81%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 3 people, 11.11%
Oral Cancer (mouth cancer): 3 people, 11.11%
Panic Disorder: 2 people, 7.41%
Nausea And Vomiting: 2 people, 7.41%
Nausea (feeling of having an urge to vomit): 2 people, 7.41%
Migraine (headache): 2 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%
Breakthrough Pain: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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