Serzone and Gemfibrozil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serzone (nefazodone hydrochloride) and Gemfibrozil (gemfibrozil). Common drug interactions include drug intolerance among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Serzone and Gemfibrozil. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

What is Gemfibrozil?

Gemfibrozil has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 18,213 Gemfibrozil users. Check the latest studies of Gemfibrozil.

On Jul, 26, 2026

28 people who take Serzone and Gemfibrozil together, and have interactions are studied.

Serzone and Gemfibrozil drug interactions.

What are the common drug interactions of Serzone and Gemfibrozil, by gender? *:

female:

Drug intolerance (drug sensitivity)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Tardive dyskinesia (a disorder that involves involuntary movements)
Abasia (inability to walk)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Renal failure acute (rapid kidney dysfunction)
Cardiac failure
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Irritability
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)

What are the common drug interactions of Serzone and Gemfibrozil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Blood glucose decreased
Cellulitis (infection under the skin)
Coma (state of unconsciousness lasting more than six hours)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dyspepsia (indigestion)
Gallbladder disorder

30-39:

n/a

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Tardive dyskinesia (a disorder that involves involuntary movements)
Type 2 diabetes mellitus
Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

50-59:

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Renal failure acute (rapid kidney dysfunction)
Abdominal pain
Anaemia (lack of blood)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

60+:

Pneumonia
Anaemia (lack of blood)
Myopathy (a muscular disease in which the muscle fibres do not function)
Myositis (inflammation of the muscles)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urine discolouration
Aortic valve replacement
Blood creatine phosphokinase increased
Cardiac failure congestive

What are the existing conditions these people have? *

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 7.14%
Diabetes: 2 people, 7.14%
Bipolar Disorder (mood disorder): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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