Silybum and Lorazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Silybum (milk thistle) and Lorazepam (lorazepam). Common drug interactions include thrombosis among females and adverse drug reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Silybum and Lorazepam. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Silybum?

Silybum has active ingredients of milk thistle. eHealthMe is studying from 779 Silybum users. Check the latest studies of Silybum.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

On Jul, 11, 2026

42 people who take Silybum and Lorazepam together, and have interactions are studied.

Silybum and Lorazepam drug interactions.

What are the common drug interactions of Silybum and Lorazepam, by gender? *:

female:

Thrombosis (formation of a blood clot inside a blood vessel)
Urinary tract infection
Visual impairment
White blood cell count increased
Fatigue (feeling of tiredness)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pyrexia (fever)
Depression
Drug hypersensitivity
Headache (pain in head)

male:

Adverse drug reaction
Bipolar disorder (mood disorder)
Abdominal pain upper
Aspartate aminotransferase increased
Biliary tract infection
Chills (felling of cold)
Dizziness
Drug ineffective
Haematemesis (vomiting of blood)
Hangover

What are the common drug interactions of Silybum and Lorazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Allergy to metals
Perfume sensitivity
Foot fracture
Muscle twitching

40-49:

Abdominal pain upper
Adverse drug reaction
Chills (felling of cold)
Drug hypersensitivity
Eye colour change
Headache (pain in head)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pyrexia (fever)
Rash
Swelling face

50-59:

Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Blood pressure decreased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug hypersensitivity
Fatigue (feeling of tiredness)
Headache (pain in head)
Heparin-induced thrombocytopenia

60+:

Angina bullosa haemorrhagica (a condition of the mucous membranes characterized by the sudden appearance of one or more blood blisters within the oral cavity)
Aphthous ulcer (mouth ulcer)
Aspartate aminotransferase increased
Biliary tract infection
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Immunosuppression
Increased appetite
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 16.67%
Insomnia (sleeplessness): 5 people, 11.90%
High Blood Pressure: 5 people, 11.90%
Pain: 4 people, 9.52%
Sleep Disorder: 3 people, 7.14%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 7.14%
Immunodeficiency: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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