Simvastatin and Empagliflozin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Empagliflozin (empagliflozin). Common drug interactions include blood ketone body increased among females and gastritis erosive among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Empagliflozin. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Empagliflozin?

Empagliflozin has active ingredients of empagliflozin. eHealthMe is studying from 1,569 Empagliflozin users. Check the latest studies of Empagliflozin.

On Jul, 14, 2026

72 people who take Simvastatin and Empagliflozin together, and have interactions are studied.

Simvastatin and Empagliflozin drug interactions.

What are the common drug interactions of Simvastatin and Empagliflozin, by gender? *:

female:

Blood ketone body increased
Blood potassium increased
Dizziness
Gastroenteritis (inflammation of stomach and intestine)
Nausea (feeling of having an urge to vomit)
Non-cardiac chest pain
Urine ketone body present
Abdominal mass (localized enlargement or swelling in the human abdomen)
Alcohol interaction
Anaemia (lack of blood)

male:

Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Melaena (the passage of black, tarry stools)
Cardiac failure chronic
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance

What are the common drug interactions of Simvastatin and Empagliflozin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

40-49:

Liver injury
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Renal impairment (severely reduced kidney function)

50-59:

Alcohol interaction
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaphylactic reaction (serious allergic reaction)
Angioedema (rapid swelling of the dermis)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Intestinal obstruction
Palpitations (feelings or sensations that your heart is pounding or racing)
Pancreatitis (inflammation of pancreas)
Peripheral embolism (sudden interruption of blood flow to an organ or body part)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
Haematochezia (passage of stools containing blood)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Sinus node dysfunction (a group of abnormal heart rhythms)
Suicidal ideation
Abdominal pain
Arthralgia (joint pain)
Blood pressure diastolic increased

What are the existing conditions these people have? *

Type 2 Diabetes: 24 people, 33.33%
High Blood Pressure: 20 people, 27.78%
Cardiac Failure: 14 people, 19.44%
Hyperlipidaemia (presence of excess lipids in the blood): 11 people, 15.28%
Dyslipidaemia (abnormal amount of lipids): 8 people, 11.11%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 8.33%
Muscle Spasms (muscle contraction): 5 people, 6.94%
Diabetes: 5 people, 6.94%
Depression: 5 people, 6.94%
Back Pain: 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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