Simvastatin and Ephedrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Ephedrine (ephedra). Common drug interactions include cerebral hypoperfusion among females and osteoporosis among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Ephedrine. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Ephedrine?

Ephedrine has active ingredients of ephedra. It is often used in weight loss. eHealthMe is studying from 1,763 Ephedrine users. Check the latest studies of Ephedrine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

61 people who take Simvastatin and Ephedrine together, and have interactions are studied.

Simvastatin and Ephedrine drug interactions.

What are the common drug interactions of Simvastatin and Ephedrine, by gender? *:

female:

Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Corneal oedema (corneal swelling)
Gamma-glutamyltransferase increased
Gastric haemorrhage (bleeding stomach)
Hepatocellular injury (liver injury)
Hypotension (abnormally low blood pressure)
Post procedural haemorrhage (post procedural bleeding)
Procedural haemorrhage (procedural bleeding)
Pulmonary embolism (blockage of the main artery of the lung)
Renal tubular necrosis (death of kidney tubules)

male:

Osteoporosis (bones weak and more likely to break)
Renal impairment (severely reduced kidney function)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Atrioventricular block complete (heart block complete)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bradycardia (abnormally slow heart action)
Cardiac murmur (an heart sound in valve abnormality)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough

What are the common drug interactions of Simvastatin and Ephedrine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Death
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Stress
Disease progression

60+:

Osteoporosis (bones weak and more likely to break)
Bone disorder
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bradycardia (abnormally slow heart action)
Cardiac murmur (an heart sound in valve abnormality)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

High Blood Pressure: 29 people, 47.54%
Mood Swings (an extreme or rapid change in mood): 27 people, 44.26%
Multiple Myeloma (cancer of the plasma cells): 20 people, 32.79%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 19 people, 31.15%
Joint Pain: 19 people, 31.15%
Fluid Retention (an abnormal accumulation of fluid in the blood): 19 people, 31.15%
Diarrhea: 19 people, 31.15%
Seasonal Allergy (allergic condition due to certain season): 16 people, 26.23%
Blood Triglycerides Decreased: 16 people, 26.23%
Pain: 10 people, 16.39%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and Ephedrine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously