Simvastatin and Feldene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Feldene (piroxicam). Common drug interactions include femur fracture among females and actinic keratosis among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Feldene. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Feldene?

Feldene has active ingredients of piroxicam. It is often used in arthritis. eHealthMe is studying from 3,913 Feldene users. Check the latest studies of Feldene.

On Aug, 01, 2026

82 people who take Simvastatin and Feldene together, and have interactions are studied.

Simvastatin and Feldene drug interactions.

What are the common drug interactions of Simvastatin and Feldene, by gender? *:

female:

Femur fracture
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Anxiety
Cataract (clouding of the lens inside the eye)
Fall
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Intervertebral disc degeneration (spinal disc degeneration)
Muscular weakness (muscle weakness)

male:

Actinic keratosis (skin disease due to sun exposure)
Adenoma benign (non-cancerous tumour -secreting)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Neuropathy peripheral (surface nerve damage)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Rectal haemorrhage (bleeding from anus)
Telangiectasia (small dilated blood vessels near the surface of the skin)
Melaena (the passage of black, tarry stools)

What are the common drug interactions of Simvastatin and Feldene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injection site pain
Injection site rash
Colitis (inflammation of colon)

30-39:

n/a

40-49:

Chronic kidney disease
Depression
Depression suicidal (suicide depressive disorder)
Diarrhoea
Duodenal ulcer
Duodenitis (inflammation of the duodenum)
Fatigue (feeling of tiredness)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Infusion related reaction
Nephrolithiasis (calculi in the kidneys)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Abnormal behaviour
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Balance disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dysphoria (generalized dissatisfaction with life)
Foot fracture
Hypotension (abnormally low blood pressure)

60+:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Syncope (loss of consciousness with an inability to maintain postural tone)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Back pain
Cataract (clouding of the lens inside the eye)
Fall
Fatigue (feeling of tiredness)
Melaena (the passage of black, tarry stools)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Urinary tract infection

What are the existing conditions these people have? *

Pain: 21 people, 25.61%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 10.98%
Infection: 9 people, 10.98%
High Blood Pressure: 9 people, 10.98%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.98%
Cardiac Disorder: 9 people, 10.98%
Stable Angina (a constant chest pain): 7 people, 8.54%
Osteoporosis (bones weak and more likely to break): 7 people, 8.54%
Depression: 7 people, 8.54%
Blood Pressure Abnormal: 7 people, 8.54%

* Approximation only. Some reports may have incomplete information.

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