Simvastatin and Gabitril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Gabitril (tiagabine hydrochloride). Common drug interactions include drug ineffective among females and obsessive-compulsive disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Gabitril. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Gabitril?

Gabitril has active ingredients of tiagabine hydrochloride. It is often used in epilepsy. eHealthMe is studying from 2,230 Gabitril users. Check the latest studies of Gabitril.

On Jul, 07, 2026

25 people who take Simvastatin and Gabitril together, and have interactions are studied.

Simvastatin and Gabitril drug interactions.

What are the common drug interactions of Simvastatin and Gabitril, by gender? *:

female:

Drug ineffective
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Renal failure (kidney dysfunction)
Abdominal pain lower
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Dyspepsia (indigestion)
Dysuria (painful or difficult urination)
Epicondylitis (tennis elbow)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

male:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Anal fissure
Anal fistula
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)
Lumbar radiculopathy (radicular pain in the low back and legs)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))

What are the common drug interactions of Simvastatin and Gabitril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Joint stiffness
Muscular weakness (muscle weakness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Peau d'orange (orange peel skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)

40-49:

Metabolic syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease)
Muscle spasms (muscle contraction)
Neck pain
Oedema peripheral (superficial swelling)
Pain in extremity
Polyp colorectal
Pulmonary embolism (blockage of the main artery of the lung)
Skin ulcer
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation

50-59:

Acute myocardial infarction (acute heart attack)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Abdominal discomfort
Actinomyces test positive
Anaphylactic reaction (serious allergic reaction)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cataract (clouding of the lens inside the eye)
Oxygen saturation decreased
Pancreatitis (inflammation of pancreas)
Psoriasis (immune-mediated disease that affects the skin)
Suicidal ideation
Type 2 diabetes mellitus
Drug ineffective

What are the existing conditions these people have? *

Pain: 7 people, 28.00%
Stress And Anxiety: 4 people, 16.00%
Partial Seizures (seizures which affect only a part of the brain at onset): 3 people, 12.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 12.00%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 12.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
Back Pain: 3 people, 12.00%
Apnea (temporary absence or cessation of breathing): 3 people, 12.00%
Affective Disorder (mental disorder): 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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