Simvastatin and Leukine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Leukine (sargramostim). Common drug interactions include sinus tachycardia among females and lymphadenopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Leukine. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Leukine?

Leukine has active ingredients of sargramostim. eHealthMe is studying from 2,188 Leukine users. Check the latest studies of Leukine.

On Jul, 29, 2026

51 people who take Simvastatin and Leukine together, and have interactions are studied.

Simvastatin and Leukine drug interactions.

What are the common drug interactions of Simvastatin and Leukine, by gender? *:

female:

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Transaminases increased
Dizziness
Anaphylactic reaction (serious allergic reaction)
Body temperature increased
Choking sensation (feeling of obstruction in respiratory system)
Fall
Hyperventilation
Incoherent (talking in a confused and unclear way)
Injection site irritation

male:

Lymphadenopathy (disease or enlargement of lymph nodes)
Hot flush (sudden feelings of heat)
Osteonecrosis of jaw (death of bone of jaw)
Anaemia (lack of blood)
Skin lesion
Infection
Neoplasm malignant (cancer tumour)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone density decreased

What are the common drug interactions of Simvastatin and Leukine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal distension
Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

20-29:

n/a

30-39:

n/a

40-49:

Headache (pain in head)
Alanine aminotransferase increased

50-59:

Myositis (inflammation of the muscles)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Pyrexia (fever)
Clostridial infection (infectious conditions by clostridium bacteria)
Diarrhoea
Infusion related reaction
Metastases to central nervous system (cancer spreads to central nervous system)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)

60+:

Lymphadenopathy (disease or enlargement of lymph nodes)
Hot flush (sudden feelings of heat)
Osteonecrosis of jaw (death of bone of jaw)
Anaemia (lack of blood)
Skin lesion
Infection
Neoplasm malignant (cancer tumour)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone density decreased

What are the existing conditions these people have? *

Prostate Cancer: 15 people, 29.41%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 7 people, 13.73%
Gynecomastia (enlargement of the gland tissue of the male breast): 7 people, 13.73%
Malignant Melanoma (skin cancer rises from melancytes): 6 people, 11.76%
Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 9.80%
High Blood Pressure: 4 people, 7.84%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 7.84%
Small Cell Lung Cancer Stage Unspecified (lung cancer in unknown stage): 3 people, 5.88%
Multiple Myeloma (cancer of the plasma cells): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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