Simvastatin and Ofirmev drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Ofirmev (acetaminophen). Common drug interactions include tachycardia among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Ofirmev. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Ofirmev?

Ofirmev has active ingredients of acetaminophen. eHealthMe is studying from 817 Ofirmev users. Check the latest studies of Ofirmev.

On Aug, 13, 2026

13 people who take Simvastatin and Ofirmev together, and have interactions are studied.

Simvastatin and Ofirmev drug interactions.

What are the common drug interactions of Simvastatin and Ofirmev, by gender? *:

female:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Nausea (feeling of having an urge to vomit)
Vomiting
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Aspartate aminotransferase increased
Asthenia (weakness)
Blood alkaline phosphatase increased
Blood bilirubin increased
Chronic kidney disease
Diarrhoea

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess limb (limb infection)
Tooth abscess (pus formation in tooth)
Anal abscess
Angioedema (rapid swelling of the dermis)
Cardiac arrest
Chronic kidney disease
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Genital abscess (build up of pus in genital)
Liver disorder (liver diseases)

What are the common drug interactions of Simvastatin and Ofirmev, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

30-39:

n/a

40-49:

n/a

50-59:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Groin abscess (pus in groin)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Subcutaneous abscess

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypokalaemia (low potassium)
Infection
Nephropathy (damage to or disease of a kidney)
Pneumonia
Drug level increased
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 23.08%
Diabetes: 3 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Pain: 2 people, 15.38%
Hypotension (abnormally low blood pressure): 2 people, 15.38%
Weight Decreased: 2 people, 15.38%
Type 2 Diabetes: 2 people, 15.38%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 15.38%
Chest Pain: 1 person, 7.69%
Drowsiness: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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