Simvastatin and Paracaine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Paracaine (proparacaine hydrochloride). Common drug interactions include choroidal neovascularisation among females and retinal exudates among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Paracaine. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Paracaine?

Paracaine has active ingredients of proparacaine hydrochloride. eHealthMe is studying from 673 Paracaine users. Check the latest studies of Paracaine.

On Jul, 17, 2026

23 people who take Simvastatin and Paracaine together, and have interactions are studied.

Simvastatin and Paracaine drug interactions.

What are the common drug interactions of Simvastatin and Paracaine, by gender? *:

female:

Choroidal neovascularisation (creation of new blood vessels in vascular layer of eye)
Eye inflammation
Vitreous floaters (spots before the eyes)
Retinal cyst (cyst on retina)
Retinal aneurysm (an abnormal dilatation of an retinal artery)
Retinal haemorrhage (bleeding from retina)
Visual acuity reduced (reduced clearness of vision)
Visual impairment
Cataract (clouding of the lens inside the eye)
Chronic kidney disease

male:

Retinal exudates (discharge from retina)
Visual acuity reduced (reduced clearness of vision)
Vitreous floaters (spots before the eyes)
Death
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Retinal haemorrhage (bleeding from retina)
Anaemia (lack of blood)
Cystoid macular oedema (fluid accumulation after cataract surgery)
Eye haemorrhage (bleeding in the eye)
Eye pain

What are the common drug interactions of Simvastatin and Paracaine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Ear infection
Eye pain
Eyelid margin crusting (crusting at the lid margins, generally worse on waking)
Haemorrhage (bleeding)
Hordeolum (small collection of pus (abscess) on the eyelid)
Retinal exudates (discharge from retina)
Retinal haemorrhage (bleeding from retina)
Vision blurred
Visual impairment

40-49:

n/a

50-59:

Anaemia (lack of blood)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood glucose increased
Blood urine present
Cerebral microangiopathy (small-vessel disease of brain)
Chronic kidney disease
Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Dizziness
Eye pain
Foot fracture

60+:

Choroidal neovascularisation (creation of new blood vessels in vascular layer of eye)
Eye inflammation
Gait disturbance
Haematoma (collection of blood outside the blood vessels)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Visual impairment
Vitreous floaters (spots before the eyes)
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 7 people, 30.43%
High Blood Pressure: 4 people, 17.39%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 17.39%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 3 people, 13.04%
Lower Respiratory Tract Infection: 3 people, 13.04%
Local Anaesthesia: 3 people, 13.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
Dyslipidaemia (abnormal amount of lipids): 3 people, 13.04%
Diabetes: 3 people, 13.04%
Retinal Oedema (swelling of retina): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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