Simvastatin and Tylox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Tylox (acetaminophen; oxycodone hydrochloride). Common drug interactions include chronic kidney disease among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Tylox. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Tylox?

Tylox has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 369 Tylox users. Check the latest studies of Tylox.

On Jul, 05, 2026

14 people who take Simvastatin and Tylox together, and have interactions are studied.

Simvastatin and Tylox drug interactions.

What are the common drug interactions of Simvastatin and Tylox, by gender? *:

female:

Chronic kidney disease
Interstitial granulomatous dermatitis (inflammation of the skin)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Skin discolouration (change of skin colour)
Anxiety
Application site pain
Application site swelling
Back disorder
Breast disorder female

male:

Dehydration (dryness resulting from the removal of water)
Renal failure (kidney dysfunction)
Blood sodium decreased
Carbon dioxide decreased
Chronic kidney disease
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Gastric cancer (stomach cancer)
Glycosylated haemoglobin increased

What are the common drug interactions of Simvastatin and Tylox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Gastric cancer (stomach cancer)
Metastatic gastric cancer (cancer types can spread to the stomach from other place)
Renal failure (kidney dysfunction)

50-59:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

60+:

Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Back disorder
Back pain
Blood bicarbonate decreased
Blood glucose increased
Blood sodium decreased
Breast disorder female

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
Neuralgia (pain in one or more nerves): 3 people, 21.43%
Oedema (fluid collection in tissue): 2 people, 14.29%
Diabetes: 2 people, 14.29%
Joint Pain: 2 people, 14.29%
Back Pain: 2 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.14%
Heart Disease: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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