Sirolimus and Afinitor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sirolimus (sirolimus) and Afinitor (everolimus). Common drug interactions include cough among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Sirolimus and Afinitor. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

On Jul, 12, 2026

17 people who take Sirolimus and Afinitor together, and have interactions are studied.

Sirolimus and Afinitor drug interactions.

What are the common drug interactions of Sirolimus and Afinitor, by gender? *:

female:

Cough
Ear infection
Blood glucose increased
Blood cholesterol increased
Hypersensitivity
Sinusitis (inflammation of sinus)
Red blood cell count increased
Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Drug level decreased

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Atonic seizures (minor type of seizure)
Herpangina (mouth blisters)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)
Drug ineffective
Fatigue (feeling of tiredness)
Vomiting
Angiofibroma (small, reddish brown or even flesh-coloured, smooth, shiny, 0.1- to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks)

What are the common drug interactions of Sirolimus and Afinitor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Headache (pain in head)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Sinus disorder (disease of sinus)
Vomiting

10-19:

Cough
Pyrexia (fever)
Atonic seizures (minor type of seizure)
Blood pressure decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Fall
Foaming at mouth (excess saliva secretion)

20-29:

Blood glucose increased
Red blood cell count increased
Dysphonia (speech disorder attributable to a disorder of phonation)
Headache (pain in head)
Rash
Rash pruritic (redness with itching)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level increased
Ear infection
Blood cholesterol increased

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hyperhidrosis (abnormally increased sweating)

40-49:

n/a

50-59:

n/a

60+:

Drug ineffective
Fatigue (feeling of tiredness)
Hospitalisation

What are the existing conditions these people have? *

Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 8 people, 47.06%
Angiomyolipoma (most common benign tumour of the kidney): 4 people, 23.53%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 17.65%
Diarrhea: 2 people, 11.76%
Carcinoid Tumor: 2 people, 11.76%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 2 people, 11.76%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 2 people, 11.76%
Brain Neoplasm Benign (non-cancerous tumour of brain): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Sirolimus and Afinitor?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously