Sodium bicarbonate and Indocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sodium bicarbonate (sodium bicarbonate) and Indocin (indomethacin). Common drug interactions include neonatal respiratory distress syndrome among females and pleural effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Sodium bicarbonate and Indocin. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

What is Indocin?

Indocin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 4,559 Indocin users. Check the latest studies of Indocin.

On Jul, 17, 2026

31 people who take Sodium bicarbonate and Indocin together, and have interactions are studied.

Sodium bicarbonate and Indocin drug interactions.

What are the common drug interactions of Sodium Bicarbonate and Indocin, by gender? *:

female:

Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Acidosis (build-up of carbon dioxide in the blood)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Blood creatinine increased
Blood urea increased
Intestinal perforation (complete penetration of the wall of the intestine)
Necrotising colitis (inflammation in the intestines (usually the colon) that can be life-threatening)
Necrotising enterocolitis neonatal (life threatening infection of intestine in newborn baby)
Neonatal disorder (disease of neonates)
Neonatal respiratory acidosis (arterial partial pressure of carbon dioxide (pa co2) is elevated above the normal range in neonate)

male:

Pleural effusion (water on the lungs)
Anxiety
Asthenia (weakness)
Bone disorder
Cardiomegaly (increased size of heart than normal)
Death
Decreased interest
Deformity (disfigurement)
Dizziness
Failure to thrive (inadequate weight gain and physical growth in children)

What are the common drug interactions of Sodium Bicarbonate and Indocin, by age (0-1 to 60+)? *:

0-1:

Abdominal distension
Acidosis (build-up of carbon dioxide in the blood)
Gastrointestinal perforation (hole in the digestive tract)
Necrotising enterocolitis (life threatening infection of intestine)
Neonatal asphyxia (a condition in which an extreme decrease in the concentration of oxygen in the body accompanied by an increase in the concentration of carbon dioxide in neonate)
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Blood creatinine increased
Blood urea increased
C-reactive protein increased

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

30-39:

Pleural effusion (water on the lungs)
Hypotension (abnormally low blood pressure)
Oedema lower limb (fluid collection in tissue of lower leg)
Cardiomegaly (increased size of heart than normal)
Pneumonia
Aortic atherosclerosis (degenerative process of aortic arteries)
Atelectasis (partial or complete collapse of the lung)
Blood sodium decreased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Extrasystoles

40-49:

Fatigue (feeling of tiredness)
Feelings of worthlessness
Flat affect (absence of emotional response to a situation)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, tactile (sensation of physical contact with an object that isn't there)
Headache (pain in head)
Lethargy (tiredness)
Loose stools
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)

50-59:

n/a

60+:

Anxiety
Emotional distress
Death
Decreased interest
Deformity (disfigurement)
Dizziness
Failure to thrive (inadequate weight gain and physical growth in children)
Gait disturbance
General physical health deterioration (weak health status)
Heart rate increased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 19.35%
Pain: 2 people, 6.45%
Nausea (feeling of having an urge to vomit): 2 people, 6.45%
Constipation: 2 people, 6.45%
Bronchopulmonary Dysplasia (chronic lung disorder in infants - enlargement of an organ or tissue by the proliferation of cells of an abnormal type): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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