Sodium fluoride and Lorazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sodium fluoride (fluoride) and Lorazepam (lorazepam). Common drug interactions include duodenal ulcer perforation among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Sodium fluoride and Lorazepam. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Sodium fluoride?

Sodium fluoride has active ingredients of fluoride. It is often used in dental cavities. eHealthMe is studying from 1,216 Sodium fluoride users. Check the latest studies of Sodium fluoride.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

68 people who take Sodium fluoride and Lorazepam together, and have interactions are studied.

Sodium fluoride and Lorazepam drug interactions.

What are the common drug interactions of Sodium Fluoride and Lorazepam, by gender? *:

female:

Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Pericarditis (inflammation of the pericardium)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Asthma
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Hand deformity
Hip arthroplasty
Hypercholesterolaemia (high levels of cholesterol in the blood)
Maternal exposure during pregnancy (use of substance during pregnancy)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Hypotension (abnormally low blood pressure)
Angiopathy (generic term for a disease of the blood vessels)
Rash
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dental caries

What are the common drug interactions of Sodium Fluoride and Lorazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting
Weight decreased
Constipation
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Impaired gastric emptying
Retching (strong involuntary effort to vomit)
Hallucination (an experience involving the perception of something not present)

20-29:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Psychotic behaviour
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Hallucination (an experience involving the perception of something not present)
Drug dependence
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)

30-39:

Constipation
Encephalitis (inflammation of the brain)
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Psychotic disorder
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Rash

40-49:

Dizziness
General physical health deterioration (weak health status)
Hypertension (high blood pressure)
Alopecia (absence of hair from areas of the body)
Decreased appetite
Drug ineffective
Drug intolerance (drug sensitivity)
Fibromyalgia (a long-term condition which causes pain all over the body)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Infusion related reaction

50-59:

Abdominal pain upper
Adjustment disorder with depressed mood
Adverse drug reaction
Adverse event
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anti-cyclic citrullinated peptide antibody positive
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)

60+:

Arthralgia (joint pain)
Nausea (feeling of having an urge to vomit)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dental caries
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Hypotension (abnormally low blood pressure)
Intermittent claudication
Periodontal disease (disease that attacks the gum and bone and around the teeth)

What are the existing conditions these people have? *

Pain: 22 people, 32.35%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 18 people, 26.47%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 16 people, 23.53%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 14 people, 20.59%
Depression: 14 people, 20.59%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 19.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 17.65%
Indigestion: 11 people, 16.18%
Headache (pain in head): 10 people, 14.71%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 14.71%

* Approximation only. Some reports may have incomplete information.

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