Sonata and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Naproxen (naproxen). Common drug interactions include bursitis among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Naproxen. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 08, 2026

56 people who take Sonata and Naproxen together, and have interactions are studied.

What are the common drug interactions of Sonata and Naproxen, by gender? *:

female:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Contusion (a type of hematoma of tissue in which capillaries)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hallucination (an experience involving the perception of something not present)
Hepatic enzyme increased
Liver disorder (liver diseases)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Onychomycosis (fungal infection of the nail)
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)

male:

Weight increased
Depression
Attention deficit/hyperactivity disorder
Blood cholesterol increased
Chills (felling of cold)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness

What are the common drug interactions of Sonata and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired fasting glucose
Pain in extremity
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight increased

20-29:

Cardiac disorder
Migraine (headache)
Type 1 diabetes mellitus
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Obesity (having too much body fat)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

30-39:

Alcoholic pancreatitis
Arthralgia (joint pain)
Asthenia (weakness)
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Haematuria (presence of blood in urine)
Head injury
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury

40-49:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Hepatic enzyme increased

50-59:

Incontinence (lack of moderation or self-control)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neuralgia (pain in one or more nerves)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Nocturia (the need to get up in the night to urinate)
Pyrexia (fever)
Swelling
Tinnitus (a ringing in the ears)
Vision blurred
Vomiting

60+:

Dizziness
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Chest pain
Coronary artery bypass
Failure to thrive (inadequate weight gain and physical growth in children)
Fall

What are the existing conditions these people have? *

Depression: 9 people, 16.07%
High Blood Pressure: 9 people, 16.07%
Stress And Anxiety: 8 people, 14.29%
Sleep Disorder: 6 people, 10.71%
Bipolar Disorder (mood disorder): 6 people, 10.71%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 8.93%
Psychotic Disorder: 4 people, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.14%
Joint Pain: 4 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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