Sonata and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Zanaflex (tizanidine hydrochloride). Common drug interactions include diabetes mellitus among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Zanaflex. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

89 people who take Sonata and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Sonata and Zanaflex, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Malaise (a feeling of general discomfort or uneasiness)
Depression
Drug abuser
Weight decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Arthralgia (joint pain)
Chest pain
Drug dependence

male:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Balance disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug abuser
Dysphagia (a condition in which swallowing is difficult or painful)
Injury
Vertigo
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Sonata and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Constipation
Depression
Drug abuser
Drug dependence
Drug ineffective
Emotional distress
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Pyelonephritis (inflammation of kidney caused by bacteria)

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chest pain
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Anxiety
Asthenia (weakness)
Balance disorder
Blindness unilateral
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

40-49:

Drug dependence
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Drug tolerance increased
Rash
Depression
Drug ineffective
Nervousness
Vomiting
Anxiety

50-59:

Aspartate aminotransferase increased
Constipation
Drug abuser
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Agitation (state of anxiety or nervous excitement)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Basophil count increased
Nausea (feeling of having an urge to vomit)

60+:

Asthenia (weakness)
Balance disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Deafness unilateral
Dysphagia (a condition in which swallowing is difficult or painful)
Eye movement disorder
General physical health deterioration (weak health status)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Loss of consciousness

What are the existing conditions these people have? *

Pain: 24 people, 26.97%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 25.84%
Depression: 9 people, 10.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 10.11%
Stress And Anxiety: 7 people, 7.87%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 6.74%

* Approximation only. Some reports may have incomplete information.

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