Spironolactone and Aczone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spironolactone (spironolactone) and Aczone (dapsone). Common drug interactions include therapeutic response unexpected among females.

The phase IV clinical study analyzes what interactions people have when they take Spironolactone and Aczone. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Aczone?

Aczone has active ingredients of dapsone. It is often used in acne. eHealthMe is studying from 1,152 Aczone users. Check the latest studies of Aczone.

On Jul, 29, 2026

66 people who take Spironolactone and Aczone together, and have interactions are studied.

Spironolactone and Aczone drug interactions.

What are the common drug interactions of Spironolactone and Aczone, by gender? *:

female:

Therapeutic response unexpected
Drug ineffective
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Pain
Burning sensation
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Depression
Diarrhoea
Dysuria (painful or difficult urination)

male:

n/a

What are the common drug interactions of Spironolactone and Aczone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bronchopulmonary aspergillosis allergic (allergic lung disorder caused by aspergillus fungi)
Cough
Nausea (feeling of having an urge to vomit)
Throat irritation
Vomiting

20-29:

Weight increased
Decreased appetite
Irritable bowel syndrome
Mixed connective tissue disease (an autoimmune disease, in which the body's defence system attacks itself)
Therapeutic response unexpected
Weight decreased
Cyst (a closed sac)
Hypoaesthesia (reduced sense of touch or sensation)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Drug ineffective
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gait disturbance
Muscular weakness (muscle weakness)
Acute respiratory distress syndrome
Adverse drug reaction
Anal fistula
Coma (state of unconsciousness lasting more than six hours)
Device dislocation
Drug specific antibody present

40-49:

Therapeutic response unexpected
Attention deficit/hyperactivity disorder
Feeling hot
Flushing (the warm, red condition of human skin)
Skin burning sensation
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)
Dyskinesia (abnormality or impairment of voluntary movement)
Dyspnoea (difficult or laboured respiration)

50-59:

Chronic kidney disease
Renal injury (kidney injury)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 36 people, 54.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 30 people, 45.45%
Stress And Anxiety: 7 people, 10.61%
Depression: 7 people, 10.61%
Irritable Bowel Syndrome: 6 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.09%
Acne Cystic (skin problems that cause pimples): 6 people, 9.09%
Migraine (headache): 4 people, 6.06%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 6.06%
Diabetes: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and Aczone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously