Spravato and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spravato (esketamine hydrochloride) and Acetaminophen (acetaminophen). Common drug interactions include mania among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Spravato and Acetaminophen. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Spravato?

Spravato has active ingredients of esketamine hydrochloride. eHealthMe is studying from 7,920 Spravato users. Check the latest studies of Spravato.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 19, 2026

19 people who take Spravato and Acetaminophen together, and have interactions are studied.

Spravato and Acetaminophen drug interactions.

What are the common drug interactions of Spravato and Acetaminophen, by gender? *:

female:

Mania (a state of abnormally elevated or irritable mood)
Muscle spasms (muscle contraction)
Sinusitis (inflammation of sinus)
Suicidal ideation
Swelling
Blood pressure increased
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Hypoaesthesia (reduced sense of touch or sensation)
Muscular weakness (muscle weakness)

male:

Drug ineffective
Presyncope

What are the common drug interactions of Spravato and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Dissociative disorder
Suicide attempt
Anxiety
Poisoning
Suicidal ideation

30-39:

Back pain
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Fluid intake reduced
Hot flush (sudden feelings of heat)
Mania (a state of abnormally elevated or irritable mood)
Muscle spasms (muscle contraction)
Sinusitis (inflammation of sinus)
Swelling
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

40-49:

Drug ineffective
Presyncope
Back pain

50-59:

n/a

60+:

Blood pressure increased
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Hypoaesthesia (reduced sense of touch or sensation)
Muscular weakness (muscle weakness)
Sedation
Panic attack

What are the existing conditions these people have? *

Depression: 12 people, 63.16%
Insomnia (sleeplessness): 8 people, 42.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 36.84%
Suicide Attempt: 4 people, 21.05%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 3 people, 15.79%
Immune System Disorder: 2 people, 10.53%
Suicidal Ideation: 2 people, 10.53%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 10.53%
Hypersensitivity: 2 people, 10.53%
Diarrhea: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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