Sprintec and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Naproxen (naproxen). Common drug interactions include drug ineffective among females and premature baby among males.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Naproxen. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

On Jul, 24, 2026

46 people who take Sprintec and Naproxen together, and have interactions are studied.

Sprintec and Naproxen drug interactions.

What are the common drug interactions of Sprintec and Naproxen, by gender? *:

female:

Drug ineffective
Abdominal discomfort
Anxiety
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gallbladder non-functioning
Hunger

male:

Premature baby

What are the common drug interactions of Sprintec and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Constipation

20-29:

Dizziness
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspnoea (difficult or laboured respiration)
Gallbladder non-functioning
Intervertebral disc protrusion (spinal disc protrusion)
Nerve injury
Peroneal nerve palsy

30-39:

Hypersensitivity
Insomnia (sleeplessness)
Abasia (inability to walk)
Injection site pain
Ankylosing spondylitis (type of arthritis affecting the spine)
Anxiety
Depression
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Drug ineffective
Eye swelling

40-49:

Psoriasis (immune-mediated disease that affects the skin)
Abdominal discomfort
Fatigue (feeling of tiredness)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

50-59:

Bipolar disorder (mood disorder)
Chronic kidney disease
Hyperhidrosis (abnormally increased sweating)
Overdose
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Weight increased

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 30.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 28.26%
Psoriasis (immune-mediated disease that affects the skin): 7 people, 15.22%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 10.87%
Drowsiness: 5 people, 10.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.70%
Migraine (headache): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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