Stivarga and Novalgin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Stivarga (regorafenib) and Novalgin (metamizole). Common drug interactions include atrial flutter among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Stivarga and Novalgin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Stivarga?

Stivarga has active ingredients of regorafenib. eHealthMe is studying from 9,539 Stivarga users. Check the latest studies of Stivarga.

What is Novalgin?

Novalgin has active ingredients of metamizole. It is often used in pain. eHealthMe is studying from 10,177 Novalgin users. Check the latest studies of Novalgin.

On Jul, 28, 2026

13 people who take Stivarga and Novalgin together, and have interactions are studied.

Stivarga and Novalgin drug interactions.

What are the common drug interactions of Stivarga and Novalgin, by gender? *:

female:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cholecystitis (infection of gallbladder)
Abdominal pain
Back pain
Bone marrow failure
Diarrhoea
Drug ineffective
Infection
Lymphoedema (localized fluid retention and tissue swelling)
Nausea (feeling of having an urge to vomit)

male:

Fatigue (feeling of tiredness)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Infection
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Mucosal inflammation (infection of mucous membrane)
Abdominal pain upper
Ascites (accumulation of fluid in the abdominal cavity)
Diarrhoea

What are the common drug interactions of Stivarga and Novalgin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Intestinal perforation (complete penetration of the wall of the intestine)
Muscle abscess (pus in muscle)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal failure chronic (long lasting kidney dysfunction)

50-59:

Abdominal pain upper
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Diarrhoea
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Haemoglobin decreased
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Oedema peripheral (superficial swelling)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)

60+:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cholecystitis (infection of gallbladder)
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Cough
Decreased appetite
Diarrhoea
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 6 people, 46.15%
Hepatocellular Carcinoma (liver cancer): 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 2 people, 15.38%
Colon Cancer: 2 people, 15.38%
Varices Oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach): 1 person, 7.69%
Gastrointestinal Stromal Tumor: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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