Suboxone and Belsomra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Belsomra (suvorexant). Common drug interactions include sleep paralysis among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Belsomra. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Belsomra?

Belsomra has active ingredients of suvorexant. It is often used in insomnia. eHealthMe is studying from 12,961 Belsomra users. Check the latest studies of Belsomra.

On Jul, 17, 2026

12 people who take Suboxone and Belsomra together, and have interactions are studied.

Suboxone and Belsomra drug interactions.

What are the common drug interactions of Suboxone and Belsomra, by gender? *:

female:

Sleep paralysis (waking up and unable to move or speak)
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Drug hypersensitivity
Hallucination (an experience involving the perception of something not present)
Memory impairment
Ocular hypertension (intraocular pressure higher than normal)

male:

Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Blood creatinine increased
Borderline personality disorder
Concussion (short loss of normal brain function in response to a head injury)
Fall
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hallucination, auditory (perceiving sounds without auditory stimulus)

What are the common drug interactions of Suboxone and Belsomra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Sleep paralysis (waking up and unable to move or speak)

40-49:

Dizziness
Headache (pain in head)
Memory impairment
Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)

50-59:

Ocular hypertension (intraocular pressure higher than normal)
Retinal pigmentation (pigmentation of retina)

60+:

Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Hallucination (an experience involving the perception of something not present)
Sleep paralysis (waking up and unable to move or speak)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Pain: 3 people, 25.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 25.00%
Hiv Infection: 3 people, 25.00%
Nausea (feeling of having an urge to vomit): 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
High Blood Cholesterol: 3 people, 25.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 16.67%
Bacterial Infection: 2 people, 16.67%
Depression: 2 people, 16.67%
Eye Disorder: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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