Suboxone and Ceftriaxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Ceftriaxone (ceftriaxone sodium). Common drug interactions include malaise among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Ceftriaxone. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

On Jul, 29, 2026

31 people who take Suboxone and Ceftriaxone together, and have interactions are studied.

Suboxone and Ceftriaxone drug interactions.

What are the common drug interactions of Suboxone and Ceftriaxone, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Post procedural complication
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Mycoplasma infection (bacterial infection)
Pyrexia (fever)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased

male:

Fatigue (feeling of tiredness)
Bradycardia (abnormally slow heart action)
Liver injury
Pneumonia
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Septic shock (shock due to blood infection)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Swelling
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Attention deficit/hyperactivity disorder

What are the common drug interactions of Suboxone and Ceftriaxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Colitis (inflammation of colon)
Pneumonia
Post procedural complication
Pyrexia (fever)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)

30-39:

Attention deficit/hyperactivity disorder
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hepatocellular injury (liver injury)
Restlessness (not able to rest)
Screaming (a long loud piercing cry)
Weight decreased

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Bone density decreased
Bone loss
Emotional distress
Multiple fractures
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pain

50-59:

Haemoglobin decreased
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)
Iron deficiency
Lactic acidosis (low ph in body tissues)
Liver injury
Pneumonia
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Septic shock (shock due to blood infection)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Breast cancer
Diarrhoea
Malignant neoplasm progression (cancer tumour came back)
Pyrexia (fever)
Stomatitis (inflammation of mucous membrane of mouth)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 19.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 19.35%
Urination - Excessive Volume: 4 people, 12.90%
Sleep Disorder: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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