Suboxone and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Hydrocortisone (hydrocortisone). Common drug interactions include pain in extremity among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Hydrocortisone. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 26, 2026

15 people who take Suboxone and Hydrocortisone together, and have interactions are studied.

Suboxone and Hydrocortisone drug interactions.

What are the common drug interactions of Suboxone and Hydrocortisone, by gender? *:

female:

Pain in extremity
Bradycardia (abnormally slow heart action)
Pneumonia
Septic shock (shock due to blood infection)
Hypoaesthesia (reduced sense of touch or sensation)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal tenderness
Asthenia (weakness)

male:

Anxiety
Pain
Intervertebral disc protrusion (spinal disc protrusion)
Lung abscess (pus in lungs)
Mucosal inflammation (infection of mucous membrane)
Prostate cancer
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Asthenia (weakness)
Blood creatinine increased

What are the common drug interactions of Suboxone and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Arthropathy
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Lung abscess (pus in lungs)
Mucosal inflammation (infection of mucous membrane)
Pain
Prostate cancer

20-29:

Abdominal pain
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Lipase increased
Pancreatic mass
Pancreatitis (inflammation of pancreas)

30-39:

Pain in extremity
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Asthenia (weakness)
Blood thyroid stimulating hormone decreased
Dehydration (dryness resulting from the removal of water)
Delirium (wild excitement)
Diarrhoea
Gastric bypass
Haemolytic anaemia (anaemia due to haemolysis)
Hypoaesthesia (reduced sense of touch or sensation)

40-49:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Fatigue (feeling of tiredness)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Quality of life decreased
Renal failure (kidney dysfunction)

50-59:

Bradycardia (abnormally slow heart action)
Pneumonia
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Infusion related reaction
Infusion site pain
Oedema peripheral (superficial swelling)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

60+:

n/a

What are the existing conditions these people have? *

Itching: 4 people, 26.67%
Drug Dependence: 4 people, 26.67%
Hepatitis C: 4 people, 26.67%
Insomnia (sleeplessness): 3 people, 20.00%
Dysthymia (mild chronic depression): 3 people, 20.00%
Premenstrual Syndrome: 3 people, 20.00%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 3 people, 20.00%
Muscle Aches (muscle pain): 3 people, 20.00%
Migraine (headache): 2 people, 13.33%
Immunodeficiency Common Variable: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and Hydrocortisone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously