Suboxone and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Naltrexone (naltrexone). Common drug interactions include pain among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Naltrexone. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,835 Naltrexone users. Check the latest studies of Naltrexone.

On Aug, 02, 2026

38 people who take Suboxone and Naltrexone together, and have interactions are studied.

Suboxone and Naltrexone drug interactions.

What are the common drug interactions of Suboxone and Naltrexone, by gender? *:

female:

Pain
Sleep attacks
Sleep paralysis (waking up and unable to move or speak)
Somnambulism (sleep walking)
Somnolence (a state of near-sleep, a strong desire for sleep)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vitamin b12 decreased
Vitamin d deficiency
Hypersensitivity
Agitation (state of anxiety or nervous excitement)

male:

Agitation (state of anxiety or nervous excitement)
Somnolence (a state of near-sleep, a strong desire for sleep)
Insomnia (sleeplessness)
Overdose
Depression
Anxiety
Constipation
Fatigue (feeling of tiredness)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Abdominal pain

What are the common drug interactions of Suboxone and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dysphoria (generalized dissatisfaction with life)
Family stress
Feeling guilty
Feeling of despair
Hallucination, auditory (perceiving sounds without auditory stimulus)
Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Mood altered (changes in mood)
Morbid thoughts (serious thoughts)
Psychomotor hyperactivity (feelings of extreme restlessness)

30-39:

Drug dependence
Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Chest pain
Depression
Emotional distress
Gastroenteritis (inflammation of stomach and intestine)
Hepatitis c
Homicidal ideation (thoughts about human killing another human)
Hyperhidrosis (abnormally increased sweating)

40-49:

Hyperhidrosis (abnormally increased sweating)
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Nerve injury
Pain
Pyrexia (fever)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Overdose
Abdominal discomfort

50-59:

Hypersensitivity
Substance abuse

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 18.42%
Drug Dependence: 7 people, 18.42%
Somatoform Pain Disorder (a mental disorder characterized by symptoms that suggest pain): 2 people, 5.26%
Depression: 2 people, 5.26%
Alcoholism (problems with alcohol): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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