Suboxone and Nitroglycerin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Nitroglycerin (nitroglycerin). Common drug interactions include supraventricular tachyarrhythmia among females and drug withdrawal syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Nitroglycerin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,250 Suboxone users. Check the latest studies of Suboxone.

What is Nitroglycerin?

Nitroglycerin has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 52,884 Nitroglycerin users. Check the latest studies of Nitroglycerin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

32 people who take Suboxone and Nitroglycerin together, and have interactions are studied.

Suboxone and Nitroglycerin drug interactions.

What are the common drug interactions of Suboxone and Nitroglycerin, by gender? *:

female:

Supraventricular tachyarrhythmia (rapid heart rhythm originating at or above the atrioventricular node)
Swelling
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Tooth infection
Vomiting
Headache (pain in head)
Fall
Premature delivery
Hyperhidrosis (abnormally increased sweating)
Acute respiratory failure

male:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Chills (felling of cold)
Eye burns
Fatigue (feeling of tiredness)
Gait disturbance
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)

What are the common drug interactions of Suboxone and Nitroglycerin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Abnormal behaviour
Aggression
Chronic kidney disease
Fear
Headache (pain in head)
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site swelling
Memory impairment
Neoplasm (tumour)

50-59:

Anoxia (low oxygen)
Arrhythmia (irregular heartbeat)
Balance disorder
Blood pressure increased
Cardiac arrest
Chills (felling of cold)
Chronic kidney disease
Circulatory collapse
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

Premature delivery
Fall
Tremor (trembling or shaking movements in one or more parts of your body)
Ulna fracture (fracture inside bone)
Blindness transient (sudden loss of vision)
Blood pressure increased
Glycosylated haemoglobin increased
Stupor (lack of critical cognitive function and level of consciousness)
Surgery
Acute respiratory failure

What are the existing conditions these people have? *

Pain: 10 people, 31.25%
Drug Dependence: 7 people, 21.88%
Stress And Anxiety: 5 people, 15.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 15.62%
High Blood Pressure: 5 people, 15.62%
Sleep Disorder: 5 people, 15.62%
High Blood Cholesterol: 4 people, 12.50%
Migraine (headache): 3 people, 9.38%
Insomnia (sleeplessness): 3 people, 9.38%
Stable Angina (a constant chest pain): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and Nitroglycerin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously