Synthroid and Norgesic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Norgesic (aspirin; caffeine; orphenadrine citrate). Common drug interactions include thrombosis among females.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Norgesic. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,205 Synthroid users. Check the latest studies of Synthroid.

What is Norgesic?

Norgesic has active ingredients of aspirin; caffeine; orphenadrine citrate. eHealthMe is studying from 330 Norgesic users. Check the latest studies of Norgesic.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

14 people who take Synthroid and Norgesic together, and have interactions are studied.

Synthroid and Norgesic drug interactions.

What are the common drug interactions of Synthroid and Norgesic, by gender? *:

female:

Thrombosis (formation of a blood clot inside a blood vessel)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Staphylococcal abscess (pus formation due to staphylococcal bacteria)
Visual field defect
Abscess limb (limb infection)
Anaemia (lack of blood)
Application site reaction
Bladder dilatation

male:

n/a

What are the common drug interactions of Synthroid and Norgesic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Application site reaction
Burning sensation
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Diplopia (double vision)
Drug effect decreased
Exercise tolerance decreased
Eye infection
Fatigue (feeling of tiredness)
Gastrointestinal viral infection (virus infection of gastrointestinal tract)
General symptom

50-59:

Bladder dilatation
Blood cholesterol increased
Blood triglycerides increased
Cellulitis (infection under the skin)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Culture urine positive
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional distress
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

60+:

Diarrhoea
Dyspnoea (difficult or laboured respiration)
Oxygen saturation decreased
Swollen tongue (swelling of tongue)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 35.71%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 2 people, 14.29%
Muscle Spasms (muscle contraction): 2 people, 14.29%
Migraine (headache): 2 people, 14.29%
Headache (pain in head): 2 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
Urinary Tract Infection: 1 person, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.14%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.14%
Constipation: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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