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Synthroid and Peppermint oil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Peppermint oil (peppermint). Common drug interactions include adverse drug reaction among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Peppermint oil. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

What is Peppermint oil?

Peppermint oil has active ingredients of peppermint. eHealthMe is studying from 1,061 Peppermint oil users. Check the latest studies of Peppermint oil.

On Jul, 17, 2026

21 people who take Synthroid and Peppermint oil together, and have interactions are studied.

Synthroid and Peppermint oil drug interactions.

What are the common drug interactions of Synthroid and Peppermint Oil, by gender? *:

female:

  1. Adverse drug reaction
  2. Asthma
  3. Blood glucose increased
  4. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  5. Dizziness
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Hypersensitivity
  8. Infusion site extravasation (flow of (blood or lymph) from infusion site)
  9. Injection site discomfort
  10. Pyrexia (fever)

male:

  1. Abdominal pain upper
  2. Chest pain
  3. Eructation (release of gas from the digestive tract)
  4. Oral pain

What are the common drug interactions of Synthroid and Peppermint Oil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Diarrhoea
  2. Abdominal distension
  3. Flatulence (flatus expelled through the anus)
  4. Gastric infection (infection of stomach)
  5. Haematochezia (passage of stools containing blood)
  6. Headache (pain in head)
  7. Oral pain
  8. Urinary tract infection
  9. Vomiting
  10. Abdominal pain upper

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 7 people, 33.33%
  2. Insomnia (sleeplessness): 3 people, 14.29%
  3. Thyroid Diseases: 2 people, 9.52%
  4. Primary Immunodeficiency Syndrome: 2 people, 9.52%
  5. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 9.52%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.52%
  7. Irritable Bowel Syndrome: 2 people, 9.52%
  8. High Blood Cholesterol: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and Peppermint oil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Synthroid and Peppermint oil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Peppermint oil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Synthroid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Peppermint oil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium and peppermint (the active ingredients of Synthroid and Peppermint oil, respectively), and Synthroid and Peppermint oil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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