Synthroid and Zicam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Zicam (zinc gluconate). Common drug interactions include ageusia among females and anosmia among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Zicam. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

What is Zicam?

Zicam has active ingredients of zinc gluconate. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 5,298 Zicam users. Check the latest studies of Zicam.

On Apr, 23, 2026

85 people who take Synthroid and Zicam together, and have interactions are studied.

What are the common drug interactions of Synthroid and Zicam, by gender? *:

female:

Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Dysgeusia (disorder of the sense of taste)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Glossodynia (a burning or painful sensation in the tongue)
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Anaemia (lack of blood)

male:

Anosmia (partial or complete loss of the sense of smell)
Ageusia (loss of taste functions of the tongue)
Pyrexia (fever)
Rash
Thrombocytopenia (decrease of platelets in blood)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Dysgeusia (disorder of the sense of taste)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Hypertension (high blood pressure)

What are the common drug interactions of Synthroid and Zicam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chest discomfort
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Loss of consciousness
Pain in extremity

30-39:

Anosmia (partial or complete loss of the sense of smell)
Ageusia (loss of taste functions of the tongue)
Glossodynia (a burning or painful sensation in the tongue)
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Chronic kidney disease
Dysgeusia (disorder of the sense of taste)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Renal failure (kidney dysfunction)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Anosmia (partial or complete loss of the sense of smell)
Ageusia (loss of taste functions of the tongue)
Dysgeusia (disorder of the sense of taste)
Urticaria (rash of round, red welts on the skin that itch intensely)
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Cataract (clouding of the lens inside the eye)
Dental caries
Diarrhoea
Dry mouth

60+:

Anosmia (partial or complete loss of the sense of smell)
Ageusia (loss of taste functions of the tongue)
Headache (pain in head)
Hypersensitivity
Abdominal discomfort
Blood pressure decreased
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug dependence
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 18 people, 21.18%

* Approximation only. Some reports may have incomplete information.

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