Tacrolimus and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tacrolimus (tacrolimus) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include pruritus among females and graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tacrolimus and Adderall. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.



On Jul, 25, 2026

90 people who take Tacrolimus and Adderall together, and have interactions are studied.

Tacrolimus and Adderall drug interactions.

What are the common drug interactions of Tacrolimus and Adderall, by gender? *:

female:

  1. Pruritus (severe itching of the skin)
  2. Urinary tract infection
  3. Abdominal discomfort
  4. Asthma
  5. Blood potassium decreased
  6. Choking sensation (feeling of obstruction in respiratory system)
  7. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  8. Eye irritation
  9. Head injury
  10. Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)

male:

  1. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  2. Sleep disorder
  3. Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
  4. Acute lung injury
  5. Alopecia (absence of hair from areas of the body)
  6. Arthralgia (joint pain)
  7. Blindness
  8. Blood glucose increased
  9. Bone pain
  10. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

What are the common drug interactions of Tacrolimus and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Arthralgia (joint pain)
  2. Bone pain
  3. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)

10-19:

  1. Blindness
  2. Cytomegalovirus infection
  3. Deafness
  4. Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
  5. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  6. Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
  7. Faecal incontinence (a lack of control over passing stool)
  8. Haemorrhage (bleeding)
  9. Hemianopia homonymous (visual field defect involving either the two right or the two left halves of the visual fields of both eyes)
  10. Humerus fracture (injury to the upper arm bone)

20-29:

  1. Small intestinal obstruction (blockage in small intestine)
  2. Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

  1. Weight decreased
  2. Abdominal discomfort
  3. Anxiety
  4. Asthma
  5. Blood potassium decreased
  6. Choking sensation (feeling of obstruction in respiratory system)
  7. Dyspnoea (difficult or laboured respiration)
  8. Fatigue (feeling of tiredness)
  9. Gait disturbance
  10. Hypersensitivity

40-49:

  1. Dizziness
  2. Dyspepsia (indigestion)
  3. Fatigue (feeling of tiredness)
  4. Haematochezia (passage of stools containing blood)
  5. Migraine (headache)
  6. Mucous stools (mucous with stool)
  7. Nausea (feeling of having an urge to vomit)
  8. Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
  9. Palpitations (feelings or sensations that your heart is pounding or racing)
  10. Presyncope

50-59:

  1. Allergy to arthropod sting
  2. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Discomfort
  5. Dry mouth
  6. Dysgeusia (disorder of the sense of taste)
  7. Erythema (redness of the skin)
  8. Muscle tightness
  9. Palpitations (feelings or sensations that your heart is pounding or racing)
  10. Skin infection

60+:

  1. Concussion (short loss of normal brain function in response to a head injury)
  2. Head injury
  3. Nausea (feeling of having an urge to vomit)
  4. Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
  5. Sinusitis (inflammation of sinus)
  6. Urinary tract infection

What are the existing conditions these people have? *

  1. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 20 people, 22.22%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 18.89%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 15.56%
  4. Drowsiness: 8 people, 8.89%
  5. Pemphigoid (tense blisters on the skin): 6 people, 6.67%
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 6.67%
  7. Iridocyclitis (inflammation of the iris and ciliary body of the eye): 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tacrolimus and Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tacrolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tacrolimus and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adderall and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus and amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Tacrolimus and Adderall, respectively), and Tacrolimus and Adderall (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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