Tecfidera and Folate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Folate (folic acid). Common drug interactions include depression among females and cryptosporidiosis infection among males.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Folate. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

On Jul, 16, 2026

21 people who take Tecfidera and Folate together, and have interactions are studied.

What are the common drug interactions of Tecfidera and Folate, by gender? *:

female:

Depression
Diarrhoea
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)
Headache (pain in head)
Memory impairment
Post procedural complication
Postoperative adhesion
Sleep disorder
Urinary retention postoperative

male:

Cryptosporidiosis infection (an intestinal disease caused by the cryptosporidium parasite)
Hypertensive crisis

What are the common drug interactions of Tecfidera and Folate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Foetal malpresentation (abnormal positions of the vertex of the fetal head relative to the maternal pelvis)
Maternal exposure during pregnancy (use of substance during pregnancy)
Depressed mood
Depression
Diarrhoea
Hypoaesthesia (reduced sense of touch or sensation)
Hypotonia (low muscle tone)

40-49:

Post procedural complication
Postoperative adhesion
Urinary retention postoperative
Pneumonia
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Hypertensive crisis
Memory impairment
Pruritus (severe itching of the skin)

50-59:

Cryptosporidiosis infection (an intestinal disease caused by the cryptosporidium parasite)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)

60+:

Headache (pain in head)
Accident
Uhthoff's phenomenon (heat intolerance)
Urinary tract infection enterococcal
Diarrhoea
Cardiac disorder
Encephalopathy (functioning of the brain is affected by some agent or condition)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Loss of consciousness
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the existing conditions these people have? *

Depression: 4 people, 19.05%
Pain: 3 people, 14.29%
Gait Disturbance: 3 people, 14.29%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 2 people, 9.52%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 9.52%
Memory Loss: 2 people, 9.52%
Hypersensitivity: 2 people, 9.52%
Affective Disorder (mental disorder): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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