Fiorinal and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Fiorinal (aspirin; butalbital; caffeine), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Cymbalta, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Fiorinal. It is created by eHealthMe based on reports of 2,551 people who have side effects when taking Fiorinal from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,877 drugs and 2,645 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

On Jul, 16, 2026

2,551 people reported to have side effects when taking Fiorinal.
Among them, 31 people (1.22%) have Osteoarthritis.

Among these 31 people:

How long have people been on Fiorinal when they have Osteoarthritis? *

What is the gender of people who have Osteoarthritis when taking Fiorinal? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Osteoarthritis when taking Fiorinal? *

What are other drugs people take besides Fiorinal? *

What are other side effects people have besides Osteoarthritis? *

Urinary Tract Infection: 10 people, 32.26%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 9 people, 29.03%
Back Pain: 9 people, 29.03%
Depression: 8 people, 25.81%
Weakness: 8 people, 25.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 25.81%
Stress And Anxiety: 8 people, 25.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 25.81%
The Flu (the flu is caused by an influenza virus): 7 people, 22.58%
Viral Pharyngitis (inflammation of the throat or pharynx caused by viral infection): 7 people, 22.58%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 7 people, 22.58%
Pain: 6 people, 19.35%
Osteoporosis (bones weak and more likely to break): 6 people, 19.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 12.90%
Joint Pain: 4 people, 12.90%
Sleep Disorder: 4 people, 12.90%
Pain In Extremity: 4 people, 12.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.68%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.68%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Fiorinal and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fiorinal:

Fiorinal (2,714 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,654 reports)

Browse all side effects of Fiorinal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,877 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,645 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aspirin; butalbital; caffeine (the active ingredients of Fiorinal) and Fiorinal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.