Levophed and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levophed (norepinephrine bitartrate) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include nausea among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Levophed and Centrum. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Levophed?

Levophed has active ingredients of norepinephrine bitartrate. eHealthMe is studying from 2,047 Levophed users. Check the latest studies of Levophed.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

On Jul, 16, 2026

13 people who take Levophed and Centrum together, and have interactions are studied.

What are the common drug interactions of Levophed and Centrum, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain
Abdominal pain upper
Anaemia (lack of blood)
Aphagia (inability or refusal to swallow)
Dysgeusia (disorder of the sense of taste)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Septic shock (shock due to blood infection)

male:

Pain
Renal failure (kidney dysfunction)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Foot amputation (loss of foot)
Multi-organ failure (multisystem organ failure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure acute (rapid kidney dysfunction)
Renal injury (kidney injury)
Anxiety

What are the common drug interactions of Levophed and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Confusional state
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Skin wound
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting

40-49:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Hypersensitivity
Hypertension (high blood pressure)
Infection
Platelet count decreased
Septic shock (shock due to blood infection)
Type 2 diabetes mellitus
Abasia (inability to walk)
Acidosis (build-up of carbon dioxide in the blood)
Dyspnoea (difficult or laboured respiration)

50-59:

Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Emotional distress
Fear
Foot amputation (loss of foot)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)

60+:

Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Pain
Renal injury (kidney injury)
Weight decreased
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

Pain: 4 people, 30.77%
Infection: 3 people, 23.08%
Staphylococcal Infection (an infection with staphylococcus bacteria): 3 people, 23.08%
Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 23.08%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 2 people, 15.38%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 15.38%
Headache (pain in head): 2 people, 15.38%
Hypotension (abnormally low blood pressure): 2 people, 15.38%
Arrhythmias (irregular heartbeat): 2 people, 15.38%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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