Fluorouracil and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fluorouracil (fluorouracil) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include nausea among females and catheter related infection among males.

The phase IV clinical study analyzes what interactions people have when they take Fluorouracil and Ziac. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Fluorouracil?

Fluorouracil has active ingredients of fluorouracil. It is often used in colon cancer metastatic. eHealthMe is studying from 97,087 Fluorouracil users. Check the latest studies of Fluorouracil.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

On Jul, 16, 2026

13 people who take Fluorouracil and Ziac together, and have interactions are studied.

Fluorouracil and Ziac drug interactions.

What are the common drug interactions of Fluorouracil and Ziac, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Hypokalaemia (low potassium)
Fatigue (feeling of tiredness)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Weakness
Cardiac arrest
Drug tolerance decreased
Haemorrhage (bleeding)

male:

Catheter related infection
Diarrhoea
Drug toxicity
Dyspnoea (difficult or laboured respiration)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Bone marrow disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myelocyte count decreased (a young white blood cell found in the bone marrow decreased)

What are the common drug interactions of Fluorouracil and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain lower
Back pain
Constipation
Dyspepsia (indigestion)
Flatulence (flatus expelled through the anus)
Gastroenteritis bacterial (inflammation of stomach and intestine by bacterial infection)

50-59:

Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Weakness
Cardiac arrest
Drug tolerance decreased
Haemorrhage (bleeding)
Blood magnesium decreased
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)

60+:

n/a

What are the existing conditions these people have? *

Rectal Cancer (cancer of rectum): 3 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 2 people, 15.38%
Colon Cancer: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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