Tramadol and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Rapamune (sirolimus). Common drug interactions include skin hypertrophy among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Rapamune. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jul, 16, 2026

81 people who take Tramadol and Rapamune together, and have interactions are studied.

Tramadol and Rapamune drug interactions.

What are the common drug interactions of Tramadol and Rapamune, by gender? *:

female:

Skin hypertrophy (skin cells enlarges)
Breast cancer
Infection
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain in extremity
Visual impairment
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)
Neoplasm progression (growth of tumour)
Therapeutic response unexpected

male:

Dyspnoea (difficult or laboured respiration)
Chest discomfort
Biliary tract disorder
Drug ineffective
Hallucination (an experience involving the perception of something not present)
Diarrhoea
Incisional hernia (hernia caused by an incompletely-healed surgical wound)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Vomiting

What are the common drug interactions of Tramadol and Rapamune, by age (0-1 to 60+)? *:

0-1:

Blood alkaline phosphatase increased

2-9:

n/a

10-19:

Aplasia (defective development or congenital absence of an organ or tissue)
Cholecystitis acute (rapid infection of gallbladder)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematemesis (vomiting of blood)
Respiratory distress (difficulty in breathing)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Viral infection

20-29:

Headache (pain in head)
Agitation (state of anxiety or nervous excitement)
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Balance disorder
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness

30-39:

Abdominal pain
Anaemia (lack of blood)
Anxiety
Blood lactate dehydrogenase increased
Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Drug ineffective
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)

40-49:

Anxiety
Asthenia (weakness)
Balance disorder
Deformity (disfigurement)
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gait disturbance
General physical health deterioration (weak health status)
Joint contracture (a permanent shortening of a muscle or joint)
Mobility decreased (ability to move is reduced)

50-59:

Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Fracture
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Gingival pain (gum pain)
Headache (pain in head)
Hepatitis c
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperhidrosis (abnormally increased sweating)
Hypovolaemia (a decreased volume of circulating blood in the body)

60+:

Chest discomfort
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Neoplasm progression (growth of tumour)
Therapeutic response unexpected
Pyrexia (fever)
Fall
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Impaired healing

What are the existing conditions these people have? *

High Blood Cholesterol: 16 people, 19.75%
High Blood Pressure: 14 people, 17.28%
Stress And Anxiety: 10 people, 12.35%
Thyroid Diseases: 9 people, 11.11%
Diabetes: 8 people, 9.88%
Blood Phosphorus Increased: 8 people, 9.88%
Nausea (feeling of having an urge to vomit): 7 people, 8.64%
Sleep Disorder: 6 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.41%
Inflammation: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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