Tekturna and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tekturna (aliskiren hemifumarate) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include arthropathy among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Tekturna and Flexeril. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Tekturna?

Tekturna has active ingredients of aliskiren hemifumarate. It is often used in high blood pressure. eHealthMe is studying from 4,730 Tekturna users. Check the latest studies of Tekturna.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 16, 2026

49 people who take Tekturna and Flexeril together, and have interactions are studied.

Tekturna and Flexeril drug interactions.

What are the common drug interactions of Tekturna and Flexeril, by gender? *:

female:

Arthropathy
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blindness unilateral
Blood calcium increased
Blood creatinine decreased
Breast swelling
Calculus urinary (stone in urinary system)
Cardiac disorder

male:

Anxiety
Coronary bypass thrombosis (coronary bypass graft completely blocked by clot)
Renal failure (kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)
Blood catecholamines decreased
Blood cortisol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardioactive drug level increased
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Chest discomfort

What are the common drug interactions of Tekturna and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Anxiety
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Diarrhoea
Eye disorder
Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperkalaemia (damage to or disease of the kidney)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)

50-59:

Chest pain
Chronic gastritis (long lasting infection of stomach lining)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Coronary bypass thrombosis (coronary bypass graft completely blocked by clot)
Costovertebral angle tenderness
Cystitis (inflammation of the wall of the bladder)
Deafness bilateral
Dehydration (dryness resulting from the removal of water)
Diaphragmatic hernia (defect or hole in the diaphragm that allows the abdominal contents to move into the chest cavity)
Duodenitis (inflammation of the duodenum)

60+:

Dyspnoea (difficult or laboured respiration)
Anxiety
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Fall
Fatigue (feeling of tiredness)
Foot fracture
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart rate irregular
Hyperlipidaemia (presence of excess lipids in the blood)

What are the existing conditions these people have? *

Cardiac Failure Congestive: 10 people, 20.41%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 18.37%
Pain: 7 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 14.29%
Urination - Excessive At Night: 5 people, 10.20%
Cardiac Amyloidosis (protein deposition in heart): 5 people, 10.20%
Back Pain: 5 people, 10.20%
Stress And Anxiety: 3 people, 6.12%
Osteoporosis (bones weak and more likely to break): 3 people, 6.12%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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