Temsirolimus and Loraz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temsirolimus (temsirolimus) and Loraz (lorazepam). Common drug interactions include nephrotic syndrome among females and disease progression among males.

The phase IV clinical study analyzes what interactions people have when they take Temsirolimus and Loraz. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Temsirolimus?

Temsirolimus has active ingredients of temsirolimus. eHealthMe is studying from 3,573 Temsirolimus users. Check the latest studies of Temsirolimus.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,694 Loraz users. Check the latest studies of Loraz.

On Jul, 09, 2026

92 people who take Temsirolimus and Loraz together, and have interactions are studied.

Temsirolimus and Loraz drug interactions.

What are the common drug interactions of Temsirolimus and Loraz, by gender? *:

female:

Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Platelet count decreased
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Mucosal inflammation (infection of mucous membrane)
Haemoglobin increased
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Nausea (feeling of having an urge to vomit)
Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Disease progression
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal pain upper
Bacteraemia (presence of bacteria in the blood)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Fall
Gait disturbance
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hypokalaemia (low potassium)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the common drug interactions of Temsirolimus and Loraz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Stomatitis (inflammation of mucous membrane of mouth)

10-19:

Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Neutropenia (an abnormally low number of neutrophils)
Stomatitis (inflammation of mucous membrane of mouth)
Hyperglycaemia (high blood sugar)
Platelet count decreased
Headache (pain in head)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Epistaxis (bleed from the nose)
Febrile neutropenia (fever with reduced white blood cells)

20-29:

n/a

30-39:

Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Immunodeficiency
Pneumonia
Asthenia (weakness)
Facial pain
Failure to thrive (inadequate weight gain and physical growth in children)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Diarrhoea

40-49:

Dehydration (dryness resulting from the removal of water)
Abdominal pain
Constipation
Hepatic haemorrhage (bleeding inside liver)
Hepatic rupture (rapture of common benign tumour of liver)
Peritoneal haemorrhage (peritoneal bleeding)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Cardiac arrest
Cardiomyopathy (weakening of the heart muscle)
Disease progression

50-59:

Nausea (feeling of having an urge to vomit)
Renal cell carcinoma (a kidney cancer)
Somnolence (a state of near-sleep, a strong desire for sleep)
Actinic keratosis (skin disease due to sun exposure)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia of malignant disease
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Colitis (inflammation of colon)
Gastric perforation (hole in stomach)
Blood creatinine increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Hypoxia (low oxygen in tissues)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pleural effusion (water on the lungs)
Pyrexia (fever)

What are the existing conditions these people have? *

High Blood Pressure: 27 people, 29.35%
Insomnia (sleeplessness): 25 people, 27.17%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 22 people, 23.91%
High Blood Cholesterol: 19 people, 20.65%
Diarrhea: 19 people, 20.65%
Nausea And Vomiting: 18 people, 19.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 15.22%
Cough: 13 people, 14.13%
Constipation: 12 people, 13.04%
Diabetes: 12 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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